Induction of cytotoxic T lyphocytes (CTLs) recognized hepatocellular carcinoma (HCC) from tumor-infiltrating lymphocytes of HCC and identification of the tumor-rejection antigen genes of HCC.

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We investigatet T Cell immunity against hepatocellular carcioma (HCC), and showed that both peripheral blood mononuclear cells (PBMC) and tumor-infiltrating lymphocytes (TIL) incubated with ingterleukin-2 alone displayd HHLA-nonrestricted but hepatic cancer-specific cytotoxicity in a majority of parients with HCC.Namely, they lysed both HCC and cholagiocellular carcinomas in an HLA-nonrestricted manner, but not any tumors with the other histological types tested, normal hepatocytes or the cells transfected with Hepatitis C virus or MUCl gene. These CTL lines and clones were phenotypically CD3^+CD4^+CD8^-. These unique CTL could play important riles in T cell immunity against HCC.