Phenotypically changed mesangial cells glomerulosclerosis associated with hyperlipidemia in primary FSGS.

表型改变的系膜细胞肾小球硬化与原发性 FSGS 中的高脂血症相关。

• 批准号: 08671306
• 负责人: HATTORI Motoshi
• 金额: $ 1.02万
• 依托单位: Tokyo Women's Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671306/
• 关键词: Nephrotic Syndrome; Hyperlipidemia; Renal injury; Glomerulosclerosis; Mesangial cell; Phenotypic change; Macrophage; Focal segmental glomerulosclerosis

Patients with steroid-resistant nephroric syndrome due to primary focal segmental glomerulosclerosis (FSGS) have a grave prognosis. The purpose of this study was to examine the pathological role of phenotypically changed mesangial cells in the process of glomerulosclerosis in primary FSGS.The results of this study indicate that 1) mesangial cells undergo phenotypic changes to myofibroblasts, 2) phenotypically changed mesangial cells to myofibroblast participate in the active scarring by de novo synthesis of interstitial collagens, and 3) growth factors originating from infiltrating macrophages may be responsible for the mesangial phenotypic changes. The interaction between mesangial cells and infiltrating macrophages is now under investigation in view of glomerular expression of macrophage-colony stimulating factor.

由于原发性局灶节段性肾小球硬化（FSGS）引起的激素耐药肾病综合征患者预后严重。本研究的目的是探讨表型改变的系膜细胞在原发性FSGS肾小球硬化过程中的病理作用，结果表明：1）系膜细胞发生表型改变为肌成纤维细胞，2）表型改变为肌成纤维细胞的系膜细胞通过重新合成间质胶原参与主动瘢痕形成，3）来源于浸润巨噬细胞的生长因子可能是系膜表型改变的原因。鉴于肾小球巨噬细胞集落刺激因子的表达，系膜细胞和浸润巨噬细胞之间的相互作用正在研究中。

项目成果

Hattori M,et al: "Mesangial phenotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" Am J Kidney Dis. 30. 632-638 (1997)

Hattori M 等人：“原发性局灶节段性肾小球硬化症中与细胞病变相关的系膜表型变化”Am J Kidney Dis。

Hattori M, et al.: "Mesangical phenotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" American Journal of Kidney Diseases. 30. 632-638 (1997)

Hattori M 等人：“与原发性局灶节段性肾小球硬化症细胞病变相关的系膜表型变化”美国肾脏病杂志。

Hattori M etal.: "Mesangial pherotypic changes associated with cellular lesions in primary focal segmental glomerulosclerosis" American Journal of Kidney Diseases. 30. 632-638 (1997)

Hattori M 等人：“与原发性局灶节段性肾小球硬化症细胞病变相关的系膜表型变化”美国肾脏病杂志。

服部 元史 他: "高脂血症病態下におけるマクロファージの糸球体内浸潤機序とその病的意義" 日本小児腎臓病学会雑誌. 10. 189-194 (1997)

Motoshi Hattori等：“高脂血症条件下巨噬细胞的肾小球内浸润机制及其病理意义”日本小儿肾病学会杂志10. 189-194（1997）。

Miyazaki K, et al.: "Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during Lipid-induced glomerulor injury in the exegenous hyperchobesterolaemic (EXHC) rat" Clinical

Miyazaki K 等人：“外源性高胆固醇血症 (EXHC) 大鼠中脂质诱导的肾小球损伤期间巨噬细胞集落刺激因子 (M-CSF) 和迁移抑制因子 (MIF) 表达的上调和单核细胞募集”临床