Phenotypically changed mesangial cells glomerulosclerosis associated with hyperlipidemia in primary FSGS.

由于原发性局灶节段性肾小球硬化（FSGS）引起的激素耐药肾病综合征患者预后严重。本研究的目的是探讨表型改变的系膜细胞在原发性FSGS肾小球硬化过程中的病理作用，结果表明：1）系膜细胞发生表型改变为肌成纤维细胞，2）表型改变为肌成纤维细胞的系膜细胞通过重新合成间质胶原参与主动瘢痕形成，3）来源于浸润巨噬细胞的生长因子可能是系膜表型改变的原因。鉴于肾小球巨噬细胞集落刺激因子的表达，系膜细胞和浸润巨噬细胞之间的相互作用正在研究中。

Patients with steroid-resistant nephroric syndrome due to primary focal segmental glomerulosclerosis (FSGS) have a grave prognosis. The purpose of this study was to examine the pathological role of phenotypically changed mesangial cells in the process of glomerulosclerosis in primary FSGS.The results of this study indicate that 1) mesangial cells undergo phenotypic changes to myofibroblasts, 2) phenotypically changed mesangial cells to myofibroblast participate in the active scarring by de novo synthesis of interstitial collagens, and 3) growth factors originating from infiltrating macrophages may be responsible for the mesangial phenotypic changes. The interaction between mesangial cells and infiltrating macrophages is now under investigation in view of glomerular expression of macrophage-colony stimulating factor.