Optimization of hyperlipidemia management among patients with rheumatoid arthritis: A patient-centered intervention development

类风湿关节炎患者高脂血症管理的优化：以患者为中心的干预措施发展

• 批准号: 10443313
• 负责人: Iris Y Navarro-Millán
• 金额: $ 17.12万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-08 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443313
• 关键词: Achievement; Active Learning; Address; Alabama; Arthritis; Attention; Attitude; Award; Belief; Cardiovascular Diseases; Caregivers; Caring; Cholesterol; Chronic; Clinical Trials; Collaborations; Communities; Data; Databases; Development; Disease remission; E-learning; Focus Groups; Foundational Skills; Foundations; Funding; Future; Geographic state; Goals; Health Insurance; Health behavior; Human; Hyperlipidemia; Hypertension; Individual; Institution; Intervention; Intervention Studies; Intervention Trial; Lipids; Low-Density Lipoproteins; Mentors; Methods; Nature; Patient Education; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Persons; Pharmaceutical Preparations; Pharmacists; Physicians; Population; Primary Care Physician; Program Evaluation; Qualitative Methods; Qualitative Research; Randomized; Research; Research Activity; Research Institute; Research Methodology; Research Personnel; Research Training; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Risk Management; Risk Reduction; SECTM1 gene; Self Administration; Self Efficacy; Self-Direction; Telephone; Testing; Training; Training Activity; Universities; Work; base; cardiovascular disorder risk; career; community based participatory research; design; evidence base; feasibility testing; improved; insurance claims; member; method development; novel; patient oriented; peer coaching; peer support; pilot test; pragmatic trial; primary outcome; programs; recruit; relative effectiveness; rheumatologist; screening; secondary outcome; shared decision making; skills; social cognitive theory; success; theories; therapy design; therapy development; tool; treatment adherence

One of the greatest success stories in rheumatology - the achievement of rheumatoid arthritis (RA) remission – is tempered by the fact that individuals RA are dramatically under evaluated and under treated to reduce cardiovascular disease (CVD) risk. This project will build the foundation for an intervention that will test the hypothesis that the patient-centered intervention tailored to the RA population that I will develop as part of this K23 will improve hyperlipidemia screening and treatment in RA, thereby reducing CVD risk. For the K23 and future projects, we will build on the Patient-Centered Outcomes Research Institute (PCORI)-funded ArthritisPower Patient Powered Research Network (PPRN). We will work in partnership with members of ArthritisPower 2,000 RA patients and caregivers in all 50 US states. In this proposal, we will develop and test the feasibility of a novel theory-driven (Using Bandura’s Social Cognitive Theory), patient-centered educational decision support/peer coaching intervention, thereby mastering foundational skills in the development and implementation of patient-engaged intervention research. The aims of this proposal are: Aim 1: To identify patient and physician barriers to CVD risk reduction in RA. During this aim, we will apply qualitative methods to elicit attitudes, beliefs and barriers regarding CVD and CVD risk reduction. Aim 2: To develop an intervention designed to optimize lipid screening and management in RA patients. We will build the intervention based on the data collected in aim 1. This one we anticipate will consist of patient education and a decision support program to facilitate screening for hyperlipidemia or initiation of lipid lowering therapy (LLT) (primary outcome) and self-efficacy in taking lipid lowering therapy and patient activation (secondary outcome). Aim 3: To pilot test the intervention developed in Aim 2. During this aim, we will apply methods related to clinical trials to test the feasibility of the newly developed intervention.

风湿病学上最大的成功案例之一 - 类风湿关节炎（RA）缓解的成就 - 由于RA的评估很大和治疗以减少 心血管疾病（CVD）风险。该项目将为干预措施奠定基础，以测试 假设我将根据RA人群量身定制的以患者为中心的干预措施作为此的一部分 K23将改善RA中的高脂血症筛查和治疗，从而降低CVD风险。对于K23和 未来的项目，我们将基于以患者为中心的结果研究所（PCORI）资助 关节炎的患者动力研究网络（PPRN）。我们将与 在美国所有50个州，关节炎的2,000名RA患者和护理人员。在此提案中，我们将开发和测试 新颖理论驱动的可行性（使用班杜拉的社会认知理论），以患者为中心的教育 决策支持/同伴教练干预，从而掌握开发中的基础技能 实施患者参与干预研究。该提案的目的是： 目标1：确定RA中CVD风险降低的患者和身体障碍。在此目标中，我们将申请 引起有关CVD和CVD风险降低的参与者，信念和障碍的定性方法。 目标2：开发旨在优化RA患者脂质筛查和管理的干预措施。我们 将根据AIM 1中收集的数据来建立干预措施。我们预期的这将包括患者 教育和决策支持计划，以促进筛查高脂血症或降低脂质的倡议 治疗（LLT）（主要结局），并在服用脂质降低治疗和患者激活方面具有自效 （次要结果）。 目标3：试点测试目标2中开发的干预措施。在此目标期间，我们将采用与 临床试验以测试新开发的干预措施的可行性。

项目成果

Barriers and facilitators for screening and treatment of hyperlipidemia among patients with inflammatory arthritis.

炎症性关节炎患者高脂血症筛查和治疗的障碍和促进因素。

• DOI: 10.1186/s41927-020-00123-w
• 发表时间: 2020
• 期刊: BMC rheumatology
• 影响因子: 2.2
• 作者: Navarro-Millán,Iris;Young,SarahR;Shurbaji,Sally;McDavid,Chastity;Cornelius-Schecter,Anna;Johnson,Bernadette;Cherrington,AndreaL;Fraenkel,Liana;Goodman,SusanM;Curtis,JeffreyR;Venkatachalam,Shilpa;Safford,MonikaM
• 通讯作者: Safford,MonikaM

Does Education Level Mitigate the Effect of Poverty on Total Knee Arthroplasty Outcomes?

• DOI: 10.1002/acr.23442
• 发表时间: 2018-06-01
• 期刊: ARTHRITIS CARE & RESEARCH
• 影响因子: 4.7
• 作者: Goodman, Susan M.;Mandl, Lisa A.;Bass, Anne R.
• 通讯作者: Bass, Anne R.

Prevalence of Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Dataset.

• DOI: 10.1002/acr2.11388
• 发表时间: 2022-04
• 期刊: ACR open rheumatology
• 影响因子: 3.4
• 作者: Lieber SB;Navarro-Millán I;Rajan M;Curtis JR;Sattui SE;Lui G;Schwartzman S;Mandl LA
• 通讯作者: Mandl LA

Outcomes of COVID-19 and Factors Associated With Its Severity Among Hospitalized Patients With and Without Systemic Rheumatic Disease During the First Wave of the Pandemic in New York City.

纽约市第一波大流行期间患有和不患有系统性风湿病的住院患者中 COVID-19 的结果及其严重程度相关的因素。

• DOI: 10.1097/rhu.0000000000001891
• 发表时间: 2023
• 期刊: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
• 作者: Siegel,CarolineH;Choi,JackyM;D'Angelo,Debra;Christos,Paul;Lally,Lindsay;Navarro-Millan,Iris;Cooke,Joseph;Goyal,Parag;Mandl,LisaA;Barbhaiya,Medha
• 通讯作者: Barbhaiya,Medha

Which patient reported outcome domains are important to the rheumatologists while assessing patients with rheumatoid arthritis?

在评估类风湿性关节炎患者时，哪些患者报告的结果领域对风湿病学家很重要？

• DOI: 10.1186/s41927-019-0087-2
• 发表时间: 2019
• 期刊: BMC rheumatology
• 影响因子: 2.2
• 作者: Jagpal,Aprajita;O'Beirne,Ronan;Morris,MelanieS;Johnson,Bernadette;Willig,James;Yun,Huifeng;Cherrington,AndreaL;Fraenkel,Liana;Curtis,JeffreyR;Safford,MonikaM;Navarro-Millán,Iris
• 通讯作者: Navarro-Millán,Iris