Optimization of hyperlipidemia management among patients with rheumatoid arthritis: A patient-centered intervention development

类风湿关节炎患者高脂血症管理的优化：以患者为中心的干预措施发展

• 批准号: 10443313
• 负责人: Iris Y Navarro-Millán
• 金额: $ 17.12万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-08 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443313
• 关键词: Achievement; Active Learning; Address; Alabama; Arthritis; Attention; Attitude; Award; Belief; Cardiovascular Diseases; Caregivers; Caring; Cholesterol; Chronic; Clinical Trials; Collaborations; Communities; Data; Databases; Development; Disease remission; E-learning; Focus Groups; Foundational Skills; Foundations; Funding; Future; Geographic state; Goals; Health Insurance; Health behavior; Human; Hyperlipidemia; Hypertension; Individual; Institution; Intervention; Intervention Studies; Intervention Trial; Lipids; Low-Density Lipoproteins; Mentors; Methods; Nature; Patient Education; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Persons; Pharmaceutical Preparations; Pharmacists; Physicians; Population; Primary Care Physician; Program Evaluation; Qualitative Methods; Qualitative Research; Randomized; Research; Research Activity; Research Institute; Research Methodology; Research Personnel; Research Training; Rheumatism; Rheumatoid Arthritis; Rheumatology; Risk; Risk Factors; Risk Management; Risk Reduction; SECTM1 gene; Self Administration; Self Efficacy; Self-Direction; Telephone; Testing; Training; Training Activity; Universities; Work; base; cardiovascular disorder risk; career; community based participatory research; design; evidence base; feasibility testing; improved; insurance claims; member; method development; novel; patient oriented; peer coaching; peer support; pilot test; pragmatic trial; primary outcome; programs; recruit; relative effectiveness; rheumatologist; screening; secondary outcome; shared decision making; skills; social cognitive theory; success; theories; therapy design; therapy development; tool; treatment adherence

One of the greatest success stories in rheumatology - the achievement of rheumatoid arthritis (RA) remission – is tempered by the fact that individuals RA are dramatically under evaluated and under treated to reduce cardiovascular disease (CVD) risk. This project will build the foundation for an intervention that will test the hypothesis that the patient-centered intervention tailored to the RA population that I will develop as part of this K23 will improve hyperlipidemia screening and treatment in RA, thereby reducing CVD risk. For the K23 and future projects, we will build on the Patient-Centered Outcomes Research Institute (PCORI)-funded ArthritisPower Patient Powered Research Network (PPRN). We will work in partnership with members of ArthritisPower 2,000 RA patients and caregivers in all 50 US states. In this proposal, we will develop and test the feasibility of a novel theory-driven (Using Bandura’s Social Cognitive Theory), patient-centered educational decision support/peer coaching intervention, thereby mastering foundational skills in the development and implementation of patient-engaged intervention research. The aims of this proposal are: Aim 1: To identify patient and physician barriers to CVD risk reduction in RA. During this aim, we will apply qualitative methods to elicit attitudes, beliefs and barriers regarding CVD and CVD risk reduction. Aim 2: To develop an intervention designed to optimize lipid screening and management in RA patients. We will build the intervention based on the data collected in aim 1. This one we anticipate will consist of patient education and a decision support program to facilitate screening for hyperlipidemia or initiation of lipid lowering therapy (LLT) (primary outcome) and self-efficacy in taking lipid lowering therapy and patient activation (secondary outcome). Aim 3: To pilot test the intervention developed in Aim 2. During this aim, we will apply methods related to clinical trials to test the feasibility of the newly developed intervention.

风湿病学最伟大的成功故事之一——类风湿关节炎（RA）缓解—— 由于个体 RA 的评估和治疗严重不足，以减少 心血管疾病（CVD）风险。该项目将为测试干预措施奠定基础 假设我将开发针对 RA 人群的以患者为中心的干预措施，作为该研究的一部分 K23 将改善 RA 的高脂血症筛查和治疗，从而降低 CVD 风险。对于 K23 和 未来的项目，我们将建立在以患者为中心的结果研究所 (PCORI) 资助的基础上 ArthritisPower 患者支持研究网络 (PPRN)。我们将与以下组织的成员合作 ArthritisPower 为美国所有 50 个州的 2,000 名 RA 患者和护理人员提供支持。在这个提案中，我们将开发和测试 新颖的理论驱动（使用班杜拉的社会认知理论）、以患者为中心的教育的可行性 决策支持/同伴辅导干预，从而掌握发展和发展的基本技能 实施患者参与的干预研究。该提案的目的是： 目标 1：确定患者和医生降低 RA CVD 风险的障碍。在此目标期间，我们将申请 定性方法来引发有关 CVD 和降低 CVD 风险的态度、信念和障碍。 目标 2：开发一种旨在优化 RA 患者血脂筛查和管理的干预措施。我们 将根据目标 1 中收集的数据制定干预措施。我们预计这一干预措施将包括患者 促进高脂血症筛查或开始降脂的教育和决策支持计划 治疗（LLT）（主要结果）以及采取降脂治疗和患者激活的自我效能 （次要结果）。 目标 3：对目标 2 中开发的干预措施进行试点测试。在此目标期间，我们将应用以下相关方法 临床试验来测试新开发的干预措施的可行性。

项目成果

Barriers and facilitators for screening and treatment of hyperlipidemia among patients with inflammatory arthritis.

炎症性关节炎患者高脂血症筛查和治疗的障碍和促进因素。

• DOI: 10.1186/s41927-020-00123-w
• 发表时间: 2020
• 期刊: BMC rheumatology
• 影响因子: 2.2
• 作者: Navarro-Millán,Iris;Young,SarahR;Shurbaji,Sally;McDavid,Chastity;Cornelius-Schecter,Anna;Johnson,Bernadette;Cherrington,AndreaL;Fraenkel,Liana;Goodman,SusanM;Curtis,JeffreyR;Venkatachalam,Shilpa;Safford,MonikaM
• 通讯作者: Safford,MonikaM

Does Education Level Mitigate the Effect of Poverty on Total Knee Arthroplasty Outcomes?

• DOI: 10.1002/acr.23442
• 发表时间: 2018-06-01
• 期刊: ARTHRITIS CARE & RESEARCH
• 影响因子: 4.7
• 作者: Goodman, Susan M.;Mandl, Lisa A.;Bass, Anne R.
• 通讯作者: Bass, Anne R.

Prevalence of Frailty in Ankylosing Spondylitis, Psoriatic Arthritis, and Rheumatoid Arthritis: Data from a National Claims Dataset.

• DOI: 10.1002/acr2.11388
• 发表时间: 2022-04
• 期刊: ACR open rheumatology
• 影响因子: 3.4
• 作者: Lieber SB;Navarro-Millán I;Rajan M;Curtis JR;Sattui SE;Lui G;Schwartzman S;Mandl LA
• 通讯作者: Mandl LA

Outcomes of COVID-19 and Factors Associated With Its Severity Among Hospitalized Patients With and Without Systemic Rheumatic Disease During the First Wave of the Pandemic in New York City.

纽约市第一波大流行期间患有和不患有系统性风湿病的住院患者中 COVID-19 的结果及其严重程度相关的因素。

• DOI: 10.1097/rhu.0000000000001891
• 发表时间: 2023
• 期刊: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
• 作者: Siegel,CarolineH;Choi,JackyM;D'Angelo,Debra;Christos,Paul;Lally,Lindsay;Navarro-Millan,Iris;Cooke,Joseph;Goyal,Parag;Mandl,LisaA;Barbhaiya,Medha
• 通讯作者: Barbhaiya,Medha

Association of cardiovascular disease and traditional cardiovascular risk factors with the incidence of dementia among patients with rheumatoid arthritis.

• DOI: 10.1016/j.semarthrit.2020.09.022
• 发表时间: 2021-03
• 期刊: Seminars in arthritis and rheumatism
• 影响因子: 5
• 作者: Sattui SE;Rajan M;Lieber SB;Lui G;Sterling M;Curtis JR;Mandl LA;Navarro-Millán I
• 通讯作者: Navarro-Millán I