DEVELOPMENT OF PORTAL OCCLUSION AS MULTIDICPLINARY TREATMENT AND ITS CLINICAL USE FOR ADVANCED HEPATOCELLULAR CARCINOMA

门静脉闭塞多学科治疗的发展及其在晚期肝细胞癌中的临床应用

• 批准号: 08671473
• 负责人: KINOSHITA Hiroaki
• 金额: $ 1.22万
• 依托单位: OSAKA CITY UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671473/
• 关键词: HEPATOCELLULAR CARCINOMA; PORTAL OCCLUSION; PERCUTANEOUS TRANSHEPATICPORTAL VEIN EMBOLIZATION; PORTAL LIGATION; LIVER REGENERATION; 門脈詰禁術

Portal occlusion by percutaneous transhepatic portal vein embolization (PTPE) or portal ligation of the one lobe of the liver causes hypertrophy and regeneration of the non-affected lobe and atrophy of the affected lobe. The number of Kuppfer cells in the affected lobe decreased. In humans, the volume of the affected lobe decreased and that of the non-affected lobe increased after the portal occlusion.Uptake of 99mTc-GSA in the affected lobe decreased and that of the non-affected lobe increased after the portal occ ; usion, whereas the uptake of the total liver did not change, indicating that the portal occlusion shifts the function of the affected lobe to the non-affected lobe. Doppler sonography showed that portal occlusion of the one lobe increase the arterial blood flow of the liver. PTPE strengthens the anticancer effect of transcatheter arterial embolization for hepatocellular carcinoma. The combination of portal occlusion and hepatic arterial infusion chemotherapy is effective for unresectable hepatocellular carcinoma.

经皮经肝门静脉栓塞术（PTPE）或肝一叶门静脉结扎造成的门静脉闭塞会导致未受累叶的肥大和再生以及受累叶的萎缩。受累叶枯否细胞数量减少。门静脉阻断后，患肝体积减小，非患肝体积增大，99 mTc-GSA摄取减少，非患肝摄取增加，而全肝摄取无变化，表明门静脉阻断使患肝功能转移到非患肝。多普勒超声显示，门静脉阻断一侧肝叶可增加肝动脉血流量。PTPE增强了经导管动脉栓塞治疗肝癌的抗癌作用。门静脉阻断联合肝动脉灌注化疗是治疗不能切除肝癌的有效方法。

项目成果

久保正二 他: "高齢者肝細胞癌症例に対する拡大肝切除術の限界と対策" 日本消化器外科学会雑誌. 29 (10). 2053-2057 (1996)

Shoji Kubo等人：“老年肝细胞癌患者扩大肝切除术的局限性和对策”日本胃肠外科杂志29（10）（1996）。

Shoji Kubo, et al.: "Liver resection for small hepatocellular carcinoma" Gastroenterology. 22. 139-145 (1996)

Shoji Kubo 等人：“小肝细胞癌的肝切除术”胃肠病学。

Taichi Shuto, et al.: "Selection of scale of hepatic resection for small hepatocellular carcinoma evaluated on the basis of recurrences examined retrospectively." Jpn J Gastroenterol Surg. 29. 998-1003 (1996)

Taichi Shuto 等人：“根据回顾性检查的复发情况评估小肝细胞癌肝切除规模的选择。”

首籐太一 他: "再発からみた小肝細胞癌切除術式のあり方" 日本消化器外科学会雑誌. 29 (5). 998-1003 (1996)

Taichi Shouto等：“从复发的角度来看小肝细胞癌的理想切除方法”日本胃肠外科杂志29（5）（1996）。

久保 正二 他: "小肝癌に対する肝切除の予後と問題点" 消化器科. 22. 139-145 (1996)

Shoji Kubo 等人：“小肝癌肝切除的预后和问题”胃肠病学 22. 139-145 (1996)