Experimental trials of a lobar emphysema model

肺叶气肿模型的实验试验

• 批准号: 08671536
• 负责人: KIRIYAMA Masanobu
• 金额: $ 1.15万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08671536/
• 关键词: lobar emphysema; bronchial stenosis model; bronchial malacia model; 気管支軟化症; 気管支狭窄症; 肺葉性気腫モデル

Background : As the major causes of lobar emphysema, segmental bronchial dysplasia has been stated. The aim of the present study was to create focal segmental bronchial malformation, observe the lobes with abnormality, and determine if simple bronchial abnormality caused lobar emphysema.Materials and Methoda : The focal segmental bronchomalacia models were created by removing the whole circumference of the left main bronchus cartilage in piglets. The continuous collapse models were created with titanium clips in rats. Bronchomalacia models were tried to create with papain saline in rats. Furthermore, the positive end-expiratory pressure (PEEP) were added in rat continuous collapse models.Results : The piglet segmental bronchomalacia was confirmed using bronchoscopy. However the left lobe became atelectatic. In the rat continuous collapse models, the stenoses were maintained. Even with PEEP,overinflation did not appear. In the rat treated with papains aline bullous chahges appeared in the lung, but it was distal lobular type of adult emphysema.Conclusion : Bronchial stenosis models and segmental bronchial malacia models were created. These simple abnormalities did not cause overinflation of the lung even using forced ventilation with PEEP.

背景：节段性支气管发育不良是肺气肿的主要病因。本研究的目的是建立局灶性节段性支气管畸形，观察有异常的肺叶，确定单纯支气管性畸形是否会导致肺气肿。材料和方法：切除仔猪左主支气管软骨周围，建立局灶性节段性支气管软化模型。用钛夹制作大鼠连续塌陷模型。用木瓜蛋白酶生理盐水复制大鼠支气管软化症模型。结果：支气管镜检查证实仔猪出现节段性支气管软化。然而，左叶变得不通电。在大鼠连续塌陷模型中，狭窄保持不变。即使有了PEEP，过度通胀也没有出现。木瓜多糖组大鼠肺内出现大疱性肺泡，但为远端小叶型成人肺气肿。结论：建立了支气管狭窄模型和节段性支气管软化模型。这些简单的异常并不会导致肺过度充气，即使在使用PEEP的情况下也是如此。