Usefulness of parathyroid hormone-related protein as a histological marker for detecting the pre-neoplastic lesion in the prostate

前列腺癌的临床意义已通过病理学特征，如肿瘤分期、分级和体积来评估。通过将肿瘤倍增时间和患者预期寿命添加到这些因素中，我们分析了106例前列腺癌的临床意义。当肿瘤倍增时间分别为2、3、4和6年时，无意义癌的发生率分别为4.8、10.6、15.4和26.9%。为探讨前列腺癌雄激素非依赖性的发生机制，我们对29例前列腺癌患者雄激素受体（AR）基因进行了检测。微卫星不稳定性分析未能发现激素依赖性和非激素依赖性癌症之间的显着差异。但在1例激素非依赖性肿瘤中发现AR基因外显子D点突变。结果提示，AR基因突变可能在激素非依赖性表型的发生中起一定作用。

Clinical significance of prostate cancer has been estimated by pathological features, such as tumor stage, grade and volume. By adding tumor doubling time and patient life expectancy to these factors, we analyzed the clinical significance of 106 prostate cancers. When tumor doubling time was assumed to be 2,3,4, and 6 years, the rate of insignificant cancer was 4.8,10.6,15.4 and 26.9%, respectively. Tumor doubling time and patient life expectancy may be important considerable factors in selecting the treatment of prostate cancer.To study the mechanism of prostate cancer to acquire the androgen independency, we analyzed androgen receptor (AR) gene form 29 prostate cancer patients. Microsatellite instability analysis failed to find a significant difference between hormone dependent and independent cancers. However, point mutation in exon D on AR gene was found in one case of hormone independent cancer. The results suggest that mutation of AR gene may pray a role in the development of hormone independent phenotype.