Usefulness of parathyroid hormone-related protein as a histological marker for detecting the pre-neoplastic lesion in the prostate
甲状旁腺激素相关蛋白作为组织学标记物用于检测前列腺癌前病变的有用性
基本信息
- 批准号:08671842
- 负责人:
- 金额:$ 1.15万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:1996
- 资助国家:日本
- 起止时间:1996 至 1997
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Clinical significance of prostate cancer has been estimated by pathological features, such as tumor stage, grade and volume. By adding tumor doubling time and patient life expectancy to these factors, we analyzed the clinical significance of 106 prostate cancers. When tumor doubling time was assumed to be 2,3,4, and 6 years, the rate of insignificant cancer was 4.8,10.6,15.4 and 26.9%, respectively. Tumor doubling time and patient life expectancy may be important considerable factors in selecting the treatment of prostate cancer.To study the mechanism of prostate cancer to acquire the androgen independency, we analyzed androgen receptor (AR) gene form 29 prostate cancer patients. Microsatellite instability analysis failed to find a significant difference between hormone dependent and independent cancers. However, point mutation in exon D on AR gene was found in one case of hormone independent cancer. The results suggest that mutation of AR gene may pray a role in the development of hormone independent phenotype.
前列腺癌的临床意义已经通过肿瘤的分期、分级和体积等病理特征进行了评估。通过将肿瘤倍增时间和患者预期寿命加入这些因素,我们分析了106例前列腺癌的临床意义。当肿瘤倍增时间为2、3、4年和6年时,无意义癌的发生率分别为4.8、10.6、15.4和26.9%。肿瘤倍增时间和患者预期寿命可能是选择前列腺癌治疗方案的重要考虑因素。为了研究前列腺癌获得雄激素非依赖性的机制,我们分析了29例前列腺癌患者的雄激素受体(AR)基因。微卫星不稳定性分析未能发现激素依赖型癌症和非激素依赖型癌症之间的显著差异。但在1例激素非依赖性癌中发现AR基因外显子D点突变。结果提示,AR基因突变可能在激素非依赖性表型的形成中起一定作用。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Masatsugu Iwamura: "Alteration of the hormones bioactivity of parathyroid hormone-related protein (PTHrP) as a result of limited proteolysis by prostate specific antigen" Urology. 48. 317-325 (1996)
Masatsugu Iwamura:“由于前列腺特异性抗原的有限蛋白水解作用,甲状旁腺激素相关蛋白(PTHrP)的激素生物活性发生改变”泌尿学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Shin Egawa: "Impact of life expectancy and tumor doubling time on the clinical significance of prostate cancer in Japan" Jpn J Clin Oncol. 27. 394-400 (1997)
Shin Ekawa:“预期寿命和肿瘤倍增时间对日本前列腺癌临床意义的影响”Jpn J Clin Oncol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Shin Egawa: "Impact of life expectancy and tumor doubling time on the clinical significance of prostate cancer in Japan." Jpn J Clin Oncol. 27. 394-400 (1997)
Shin Ekawa:“预期寿命和肿瘤倍增时间对日本前列腺癌临床意义的影响。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Toyoaki Uchida: "Mutation and microsatellite instability analysis of the androgen receptor gene in human prostate cancer" Int J oncol. 11. 551-556 (1997)
Toyoaki Uchida:“人类前列腺癌雄激素受体基因的突变和微卫星不稳定性分析”Int J oncol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Masatsugu Iwamura: "Alteration of the hormone bioactivity of parathyroid hormone-related protein(PTHrP)as a result of limited proteolysis by prostate antigen." Urology. 48. 317-325 (1996)
Masatsugu Iwamura:“由于前列腺抗原的有限蛋白水解作用,甲状旁腺激素相关蛋白(PTHrP)的激素生物活性发生了改变。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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IWAMURA Masatsugu其他文献
Analysis of immune responses in prostate cancer patients received low-dose-rate prostate brachyterapy
接受低剂量率前列腺近距离治疗的前列腺癌患者的免疫反应分析
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
KUBO Makoto;SATOH Takefumi;ISHIYAMA Hiromichi;TABATA Ken-ichi;TSUMURA Yasuhide;IGARASHI Yasuyuki;IWAMURA Masatsugu;BABA Shiro;HAYAKAWA Kazushige;OBATA Fumiya - 通讯作者:
OBATA Fumiya
IWAMURA Masatsugu的其他文献
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{{ truncateString('IWAMURA Masatsugu', 18)}}的其他基金
Proteomic analysis of cyst fluid associated with renal cell carcinoma
肾细胞癌相关囊液的蛋白质组学分析
- 批准号:
22591776 - 财政年份:2010
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Searching for new biomarkers of Renal cell carcinoma based on proteomic approach
基于蛋白质组学方法寻找肾细胞癌新的生物标志物
- 批准号:
18591772 - 财政年份:2006
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Effect of macrophages transduced with an adenoviral vector expressing interleukin-12 in prostate cancer
表达白介素 12 的腺病毒载体转导的巨噬细胞对前列腺癌的影响
- 批准号:
15591712 - 财政年份:2003
- 资助金额:
$ 1.15万 - 项目类别:
Grant-in-Aid for Scientific Research (C)