Targeting TGF-beta proteins to control animal reproduction

靶向 TGF-β 蛋白来控制动物繁殖

• 批准号: DP220101179
• 负责人: Dr Kelly Walton
• 金额: $ 35.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101179
• 关键词: Targeting; TGF; beta; proteins; control

This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.

该项目旨在开发一套新的生物制剂来控制雌性哺乳动物的生育能力。该项目希望证明，靶向单一类别的卵巢蛋白将促进或抑制卵子的产生。该项目的预期成果是：(1)通过增加畜群/群的规模，改变家畜的饲养，这将为农业带来重大利益；(2)为同伴/野生物种提供一种非外科手术的避孕方法，这将解决这些动物在控制生育能力方面尚未得到满足的巨大需求。