Targeting TGF-beta proteins to control animal reproduction

靶向 TGF-β 蛋白来控制动物繁殖

• 批准号: DP220101179
• 负责人: Dr Kelly Walton
• 金额: $ 35.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101179
• 关键词: Targeting; TGF; beta; proteins; control

This project aims to develop a suite of novel biologics to control fertility in female mammals. This project expects to demonstrate that targeting a single class of ovarian proteins will enhance or inhibit egg production. The expected outcomes of this project are to (1) transform the breeding of livestock animals, which should provide significant benefits to the agricultural industry, through increased herd/flock sizes, and (2) provide a non-surgical method of contraception in companion/feral species, which should address the large unmet need for fertility control in these animals.

该项目旨在开发一套新的生物制剂来控制雌性哺乳动物的生育能力。该项目预计将证明，针对单一类别的卵巢蛋白质将增强或抑制卵子生产。该项目的预期成果是：（1）通过增加畜群/羊群规模，改变牲畜的饲养方式，这将为农业产业带来重大利益;（2）为伴侣/野生物种提供非手术避孕方法，这将解决这些动物生育控制方面大量未满足的需求。