课题基金 / 基金详情

AUTOANTIBODIES AGAINST LENS ARE CYTOTOXIC TO LENS EPITHELIAL CELLS CAUSING AGE-RELATED CATARACT.

AUTOANTIBODIES AGAINST LENS ARE CYTOTOXIC TO LENS EPITHELIAL CELLS CAUSING AGE-RELATED CATARACT.
针对晶状体的自身抗体对晶状体上皮细胞具有细胞毒性，导致年龄相关性白内障。
批准号：
08672039
负责人：
OHARA Kunitoshi
金额：
$1.41万
依托单位：
NIPPON MEDICAL SCHOOL
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
项目状态：
已结题
起止时间：
1996 至 1997
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672039/
关键词：
AGE-RELATED CATARACTAUTOIMMUNEHUMAN LENS EPITHELIAL CELL CULTUREBETA-CRYSTALLINCOMPLEMENTCELL DEATHDIFFERENTIATIONHUMAN SERAベータ-・クリスタリン細胞障害

项目摘要

项目成果

OHARA Kunitoshi的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
Circulating autoantibodies against lens antigens are prevalent in patients with age-related cataract (ARC), but their pathogenic significance is unknown. We hypothesized that these autoantibodies are cytotoxic for lens epithelial cells (LECs). To test this hypothesis, we incubated LECs with mouse polyclonal antibodies against beta-crystallin (anti-beta) in the presence or absence of guinea pig complement. We found that anti-beta in the presence of the complement bound to and killed human LECs (HLECs). Sera obtained from patients with ARC also were cytotoxic to HLECs. These results support the hypothesis that autoantibodies against lens antigens are cytotoxic to LECs, and that cell death may involve complement-mediated pathways.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Nobuhiro Ibaraki: "Anti-β-crystallin antibodies(mouse)or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture." Experimental Eye Research. 64. 229-238 (1997)
Nobuhiro Ibaraki：“抗 β-晶状体蛋白抗体（小鼠）或患有年龄相关性白内障的人的血清对培养的晶状体上皮细胞具有细胞毒性。” 64. 229-238 (1997)。
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Nobuhiro Ibaraki: "Anti-β-crystallin antibodies (mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture" Experimental Eye Research. 64(発表予定). (1997)
Nobuhiro Ibaraki：“抗 β-晶状体蛋白抗体（小鼠）或患有年龄相关性白内障的人的血清对培养物中的晶状体上皮细胞具有细胞毒性”实验眼研究 64（待提交）。
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Nobuhiro Ibaraki: "Anti-beta-crystallin antibodies (mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture." Experimental Eye Research. 64. 229-238 (1997)
Nobuhiro Ibaraki：“抗β-晶状体蛋白抗体（小鼠）或患有年龄相关性白内障的人的血清对培养的晶状体上皮细胞具有细胞毒性。”
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Nobuhiro Ibaraki: "Anti-β-crystallin antibodies(mouse) or sera from humans with age-related cataract are cytotoxic for lens epithelial cells in culture." Experimental Eye Research. 64. 229-238 (1997)
Nobuhiro Ibaraki：“抗 β-晶状体蛋白抗体（小鼠）或患有年龄相关性白内障的人的血清对培养的晶状体上皮细胞具有细胞毒性。” 64. 229-238 (1997)。
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Full-automatic measurement system for the corneal endothelial cell morphology in vivo
  • 批准号：
    60870062
  • 项目类别：
    Grant-in-Aid for Developmental Scientific Research
  • 资助金额：
    $7.04万
  • 财政年份：
    1985
  • 负责人：
    OHARA Kunitoshi
  • 依托单位：
    Jichi Medical School
国内基金
海外基金
Autoimmune diseases therapies: variations on the microbiome in rheumatoid arthritis