Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease

构建引领 — 建立合作伙伴关系,将暴露组与自身免疫性疾病联系起来

基本信息

项目摘要

Project Summary/Abstract Environmental health researchers have identified a substantial role of the exposome in development and progression of many complex diseases, including autoimmunity. We and others have identified relationships between specific exposures, such as wildfire smoke and Epstein-Barr virus, and changes to the immune system in people with and without autoimmune disease. The overarching goal of the proposed studies is to establish a collaborative interdisciplinary research team focused on understanding the role of the exposome in autoimmune disease, specifically rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), to participate in the Exposome in Autoimmune Diseases Collaborating Teams, EXACT Network. In Specific Aim 1, we will develop a strong, formalized partnership between the Benaroya Research Institute (BRI) in Seattle and the Oklahoma Medical Research Foundation (OMRF) in Oklahoma City to define associations between a broad spectrum of environmental exposures and clinical severity/flares in RA and SLE. BRI and OMRF maintain some of the largest national biorepositories of samples from individuals with RA and SLE, with longitudinal measures of disease and ability to recontact participants. We will harmonize data related to clinical features of these autoimmune diseases across sites (e.g., autoantibodies and severity measures), and implement new, shared protocols at each site for collection of both data and samples relevant to exposome measurements. In Aim 2, we will organize and host two summit meetings for autoimmune disease researchers, environmental health and toxicology experts, geneticists, clinicians, patients, EXACT Network sites, and other stakeholders. The first summit will define and prioritize questions that are of critical importance to this emerging field, and the second summit will design an implementation plan to address these questions. In Aim 3, we will develop the teams and resources needed to conduct two pilot studies to investigate the role of the exposome in RA and SLE. The first pilot study proposes to determine the impact of wildfire smoke on the immune landscape in RA and the second pilot will determine environmental influences in SLE using geocoding. This work will establish collaborative teams and a research framework ready to address the future priorities of the EXACT Network focusing on understanding the role that exposures play in shaping autoimmune disease development and progression.
项目总结/文摘

项目成果

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Jane Hoyt Buckner其他文献

Jane Hoyt Buckner的其他文献

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{{ truncateString('Jane Hoyt Buckner', 18)}}的其他基金

T cells promoting transitions toward autoimmunity
T 细胞促进向自身免疫的转变
  • 批准号:
    10658696
  • 财政年份:
    2023
  • 资助金额:
    $ 49.27万
  • 项目类别:
Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease (Admin Supp)
构建领先 — 建立合作伙伴关系,将暴露组与自身免疫性疾病联系起来(管理补充)
  • 批准号:
    10933073
  • 财政年份:
    2023
  • 资助金额:
    $ 49.27万
  • 项目类别:
Harnessing engineered T regulatory cells to promote beta cell health in T1D
利用工程化 T 调节细胞促进 1 型糖尿病 (T1D) 中 β 细胞的健康
  • 批准号:
    10436687
  • 财政年份:
    2022
  • 资助金额:
    $ 49.27万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10420945
  • 财政年份:
    2022
  • 资助金额:
    $ 49.27万
  • 项目类别:
Harnessing engineered T regulatory cells to promote beta cell health in T1D
利用工程化 T 调节细胞促进 1 型糖尿病 (T1D) 中 β 细胞的健康
  • 批准号:
    10605317
  • 财政年份:
    2022
  • 资助金额:
    $ 49.27万
  • 项目类别:
Clinical Core
临床核心
  • 批准号:
    10598119
  • 财政年份:
    2022
  • 资助金额:
    $ 49.27万
  • 项目类别:
Mechanisms of IL-6 mediated T cell pathogenesis in autoimmunity
IL-6介导的自身免疫T细胞发病机制
  • 批准号:
    10204509
  • 财政年份:
    2020
  • 资助金额:
    $ 49.27万
  • 项目类别:
Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapy
定义 T 细胞对肿瘤和自身抗原的反应特征作为检查点治疗反应的预测因子
  • 批准号:
    10248349
  • 财政年份:
    2019
  • 资助金额:
    $ 49.27万
  • 项目类别:
Defining the features of T cell response to tumor and self-antigens as predictors of response to checkpoint therapy
定义 T 细胞对肿瘤和自身抗原的反应特征作为检查点治疗反应的预测因子
  • 批准号:
    10480055
  • 财政年份:
    2019
  • 资助金额:
    $ 49.27万
  • 项目类别:
Anti-tumor and autoimmunity signatures in Down syndrome
唐氏综合症的抗肿瘤和自身免疫特征
  • 批准号:
    10848979
  • 财政年份:
    2019
  • 资助金额:
    $ 49.27万
  • 项目类别:

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