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Micro vascular architecture and bone formation after Guided Bone Regeneration

引导骨再生后的微血管结构和骨形成

基本信息

批准号：
08672105
负责人：
MATSUO Masato
金额：
$ 1.54万
依托单位：
Kanagawa Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672105/
关键词：
GBR SEM resin cast microcirculation GBR PTFE

项目摘要

Guided bone regeneration (GBR) is a periodontal treatment to restore the loss of alveolar bone. In the present study, nonresorbable and resorbable membranes were applied to the extraction socket / artificial bone cavity and vascular resin cast model was examined under scanning electron microscopy (SEM).In the observation of nonresorbable membrane, bone aposition was observed upward and sideways beyond the alveolar crest after 14 days postoperation. Regenerated blood vessels were distributed in the newly formed porous bone.30 days following surgery, In the center portion of the extraction socket, newly-formed vascular network and regenerated bone were observed. A flat vascular network from the periosteum was observed on the GBR membrane. 60 days following surgery, Regenerated bone and a vascular network of the bone marrow were observed.In the observation of resorvable membrane, 90 days after the operation, the membrane, which showed evidence of being resorbed, was found between the superficial vascular network of the oral mucosa and the regenerated alveolar bone. Blood vessels from the periosteum increased in caliber as they passed through the resorbed part of the membrane.These results indicate that regardless of what type of membrane is used, it only acts as a barrier preventing the oral mucosa from migrating apically to the socket, thereby creating an environment that promotes the proliferation of cells in the socket.From the viewpoint of the microcirculation, the level reached by blood vessels arising from the periosteum might play an important role in determining the final height of regenerated alveolar bone.

引导骨再生（GBR）是一种牙周治疗，以恢复牙槽骨的损失。将不可吸收膜和可吸收膜分别应用于拔牙窝/人工骨腔，扫描电镜下观察血管树脂铸型模型，术后14 d不可吸收膜组可见牙槽嵴上方和侧面的骨沉积。再生血管分布于新生多孔骨中。术后30 d，拔牙窝中心部可见新生血管网和再生骨。在GBR膜上观察到来自骨膜的扁平血管网。术后60天观察到再生骨和骨髓血管网，术后90天观察到口腔粘膜浅层血管网和再生牙槽骨之间的可吸收膜有被吸收的迹象。从骨膜出来的血管在通过膜的吸收部分时口径增大。这些结果表明，无论使用哪种类型的膜，它都只是作为阻止口腔粘膜向牙槽顶迁移的屏障，从而创造了促进牙槽内细胞增殖的环境。从微循环的角度来看，从骨膜发出的血管所达到的高度可能在决定再生牙槽骨的最终高度中起重要作用。