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The approach for bone regeneration using PRP (Platelet-Rich Plasma). Morphological observation of microcirculation after alveolar bone adaptation.

使用 PRP（富血小板血浆）进行骨再生的方法。

基本信息

批准号：
15591954
负责人：
MATSUO Masato
金额：
$ 1.86万
依托单位：
Kanagawa Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

IntroductionBone regeneration therapy has been examined by various techniques. It is considered that PRP promotes angiogenesis and bone regeneration. In this study, microvascular changes and bone formation after synthetic graft using PRP was examined under a scanning electronic microscope (SEM). Microvascular resin cast is a method to observe the vasculature. A clear, three-dimensional image can be observed through the complete infusion of a injected synthetic resin up to the capillaries.Materials and MethodsSix beagle dogs were used to experimental animals. The mandiblal bone of premolars of 4 teeth on both sides were extracted. These extracted sockets were divided into 4 groups. PRP and synthetic bone graft material (TCP ; Tricaluciumphosphate) was applied to the sockets of one side. One side is used to the control.Results and DiscussionIn the tooth extraction group, vascular regeneration is promoted by applying PRP to tooth socket. A newly formed bone had occurred between these blood vessels. However, without scaffold, PRP doesn't recover the bone height. In the TCP graft group of with the application of PRP, regeneration of rich blood vessel was seen around the TCP glanules. The absorption of the TCP was advanced clearly. The trabeculae was reproducted. Because TCP worked for scaffold, bone height was recovered.ConclusionThese results suggest that application of PRP greatly advanced the bone regeneration. It is understood that PRP promotes the regeneration of the blood vessels and the bone.

骨再生治疗已通过各种技术进行了检查。认为PRP促进血管生成和骨再生。在这项研究中，微血管的变化和骨形成后，人造移植物使用PRP在扫描电子显微镜（SEM）下进行了检查。微血管树脂铸型是一种观察血管的方法。一个清晰的，三维图像可以观察到通过完全注入的合成树脂的毛细血管。材料和方法6只比格犬实验动物。拔除两侧4颗前磨牙的下颌骨。将这些拔牙窝分为4组。将PRP和合成植骨材料（TCP ;磷酸三钙）应用于一侧牙槽。结果与讨论拔牙组牙槽窝局部应用PRP可促进血管再生。在这些血管之间出现了一个新形成的骨骼。然而，没有支架，PRP不能恢复骨高度。在应用PRP的TCP移植物组中，TCP颗粒周围可见丰富的血管再生。TCP的吸收明显提前。骨小梁再生。结论PRP的应用可促进骨组织再生。据了解，PRP促进血管和骨骼的再生。