Evaluation of oxygen toxicity by Hyperbaric Oxygen Therapy (HBO)

高压氧治疗(HBO)评估氧毒性

基本信息

  • 批准号:
    08672580
  • 负责人:
  • 金额:
    $ 0.32万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1996
  • 资助国家:
    日本
  • 起止时间:
    1996 至 1997
  • 项目状态:
    已结题

项目摘要

Oxygen toxicity has been a critical point against the using oxygen for the therapy except classic toxicity like as Paul Bent or Laurain Smith effect. Oxygen is so useful for ishemic tissues and we consider it as an useful treatment as subsidiary one.While, there have not been made clear the oxygen toxicity concerned with Hyperbaric oxygen Therapy (HBO) though it has been popular since Beraema's proposal of so called life without blood in 1960.This research is how to estimote the changes of oxygen free radicals in plasma as an indicator against oxygen toxicity. We have succeeded to trap hydroxyl-radical by 5・5-dymethl-N-oxide (DMPO) using Erectro spin trapping resonance (ESR). Hydroxyl-radicals have been followed through not only animal experiments but clinic data from HBO patients. Eventually, it estimates that the critical levels of HBO is 3ATA 60minutes exposure by pure oxygen and Hydropxyl radicals values must becomes and not return to normal lebels before HBO.This indicates us the dose of oxygen breathing under high pressure conditions. We have also found the activity of superoxide dismutase (SOD) and this reserch shows us am index of HBO tables when the patients must be demanded the application of HBO.
除了经典的毒性如Paul Bent或Laurain Smith效应外,氧毒性一直是反对使用氧进行治疗的关键点。氧对缺血性组织有很大的作用,我们认为它是一种辅助治疗手段,然而,高压氧治疗(HBO)自1960年Beraema提出"无血生活“以来,一直受到人们的欢迎,但其氧毒性却一直不清楚。我们成功地用5·5-二甲基-N-氧化物(DMPO)作自旋捕集共振(ESR)捕获了羟基自由基。羟自由基不仅在动物实验中,而且在高压氧患者的临床资料中也有研究。最后估计高压氧暴露60分钟的临界水平为3ATA,羟自由基值必须达到且不能恢复到高压氧暴露前的正常水平,这为高压条件下的吸氧量提供了参考。超氧化物歧化酶(SOD)活性的测定为高压氧治疗提供了一个指标。

项目成果

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MANO Yoshihiro其他文献

MANO Yoshihiro的其他文献

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{{ truncateString('MANO Yoshihiro', 18)}}的其他基金

Re-examining the concept of polar auxin transport by the analysis of gene expression involved in auxin biosynthesis
通过分析生长素生物合成中涉及的基因表达重新审视极性生长素转运的概念
  • 批准号:
    23658096
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Analysis of defense mechanism against Agrobacterium-reinfection in plants regenerated from hairy roots.
毛状根再生植物抗农杆菌再感染的防御机制分析。
  • 批准号:
    06806010
  • 财政年份:
    1994
  • 资助金额:
    $ 0.32万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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  • 财政年份:
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