Investigating non-canonical RNA processing in developing spermatids

RNA结合了DNA的信息含量和蛋白质的物理性质。这些特点意味着它正在成为新知识、生物学基本问题的答案以及生物技术应用的主要参与者。该项目旨在了解非规范RNA处理事件如何控制基因表达。信使核糖核酸是如何在转录后处理，以选择性地储存、翻译、稳定或腐烂以控制发育。RNA驱动的过程对精子细胞的形态发生和分化进行编程，但对其机制知之甚少。揭示广泛的细胞质聚腺苷酸化的功能，这是小鼠生育所必需的，可能会推动下一波RNA生物技术应用。

RNA combines the information content of DNA and the physical properties of proteins. These features mean it's emerging as a major player for new knowledge; for answers to fundamental questions in biology, and for applications in biotechnology. This project aims to understand how non-canonical RNA processing events control gene expression. How mRNA is processed post-transcriptionally for selective storage, translation, stabilisation or decay to control development. RNA-driven processes program morphogenesis and differentiation of spermatids, but via mechanisms only poorly understood. Uncovering the function of extensive cytoplasmic polyadenylation, which is essential for murine fertility, may fuel the next wave of RNA biotech applications.