3'UTR switching in eukaryotic cells

该项目旨在揭示转录后基因表达调控机制和功能的基本保守特征。RNA系统连接DNA的执行功能和蛋白质的工作者功能。信使核糖核酸通常决定蛋白质合成的水平、时间和位置。该项目将使用RNA测序和定制的生物信息学来探测全球RNA动力学。它结合了酵母遗传学和RNA技术，重点研究了真核细胞生物学中的3‘非翻译区(UTR)动态。该项目希望显著促进对真核基因功能和基因调控的理解，这在个性化基因组医学时代是至关重要的。

The project aims to uncover conserved features fundamental to the mechanism and function of post-transcriptional gene-expression control. RNA systems interface the executive functions of DNA and the worker functions of proteins. mRNA often dictates the level, timing and location of protein synthesis. This project will use RNA-sequencing and bespoke bioinformatics to probe global RNA-dynamics. Mixing yeast-genetics with RNA-technologies, it focuses on 3’ untranslated region (UTR) dynamics in eukaryotic cell biology. This project expects to significantly advance the understanding of eukaryotic gene function and gene regulation, critical in an age of personalised genomic medicine.