Console renewal 400 MHz NMR spectrometer with automatic sample changer

控制台更新 400 MHz NMR 波谱仪，带自动进样器

• 批准号: 528513700
• 金额: --
• 依托单位: Ruprecht-Karls-Universität Heidelberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2023
• 资助国家: 德国
• 起止时间: 2022-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/528513700?language=en
• 关键词: Console; renewal; 400; MHz; NMR

We apply the renewal of a 400 MHz NMR spectrometer using the existing superconducting magnet. The entire electronics ("console") are to be renewed, as well as the automatic sample changer. These components are outdated and prone to failure. Service from the manufacturer for these components is no longer assured ("End of Service" was in 2018 and 2016, respectively). Furthermore, the existing device can only be operated with outdated software that has not been maintained or renewed by the manufacturer since 2015. Therefore, the console and sample changer are to be replaced with new components so that the continued operation of the spectrometer is assured in the coming years.Some of the existing components can continue to be used with the new console, provided that they are compatible with the new instrument. In addition to the superconducting magnet, this concerns the shim system as well as the NMR probes and the cooling devices for measurements at variable temperature. The existing instrument is used for NMR measurements by many research groups at the Inorganic Chemistry Institute and is used to capacity. The typical application is 1D and 2D measurements of diamagnetic compounds of NMR nuclei with high to medium sensitivity such as 1H, 2H, 13C, 19F, 31P, 11B, 119Sn, 7Li. In addition, variable temperature measurements (typical range -90°C to +120°C) are often performed. In addition, measurements of paramagnetic metal complexes are of great importance. Here, a magnetic field strength of 9.4 T (i.e. 400 MHz 1H frequency) represents a good compromise between measurement sensitivity, pulse excitation width, relaxation behavior and signal dispersion. The instrument is embedded in the NMR infrastructure of the two molecular chemistry institutes, the Inorganic and the Organic Chemistry Institute of Heidelberg University (ACI and OCI, respectively). The majority of the samples at the requested instrument come from research groups at the ACI, which are all located in close proximity to the instrument. This allows measurements of very sensitive samples as well as kinetic measurements shortly after reaction start. Measurements that require a much higher sensitivity can be made on the instruments with cryo probes available at ACI and OCI. Working groups of other institutes of Heidelberg University, which need NMR measurements less frequently (e.g. from the Institute of Physical Chemistry or Biochemistry), will also be provided with the requested equipment.

我们应用更新的400兆赫核磁共振谱仪使用现有的超导磁体。整个电子设备（“控制台”）以及自动进样器都需要更新。这些组件已经过时，容易出现故障。这些组件的制造商服务不再有保证（“服务终止”分别于2018年和2016年）。此外，现有设备只能使用自2015年以来制造商未维护或更新的过时软件进行操作。因此，控制台和进样器将更换为新的部件，以确保光谱仪在未来几年内继续运行。一些现有的部件可以继续与新的控制台一起使用，前提是它们与新仪器兼容。除了超导磁体之外，这还涉及匀场系统以及NMR探头和用于在可变温度下进行测量的冷却装置。现有的仪器被无机化学研究所的许多研究小组用于NMR测量，并已达到最大容量。典型的应用是1D和2D测量具有高至中等灵敏度的NMR核的抗磁性化合物，例如1H，2 H，13 C，19 F，31 P，11B，119 Sn，7 Li。此外，还经常进行可变温度测量（典型范围为-90 ° C至+120 ° C）。此外，顺磁性金属配合物的测量也非常重要。这里，9.4 T的磁场强度（即400 MHz 1H频率）代表测量灵敏度、脉冲激励宽度、弛豫行为和信号色散之间的良好折衷。该仪器嵌入在海德堡大学无机和有机化学研究所（分别为ACI和OCI）这两个分子化学研究所的NMR基础设施中。所要求的仪器上的大多数样品来自ACI的研究小组，这些研究小组都位于仪器附近。这允许测量非常敏感的样品以及在反应开始后不久进行动力学测量。需要更高灵敏度的测量可以在ACI和OCI提供的带有低温探头的仪器上进行。海德堡大学其他研究所的工作组需要核磁共振测量的频率较低（例如物理化学或生物化学研究所），也将获得所需的设备。