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Development of a high-frequency ultrasound system with high-speed electronic scan probes for evaluating fine structures and function in vivo

开发具有高速电子扫描探头的高频超声系统，用于评估体内精细结构和功能

基本信息

批准号：
10358020
负责人：
KITABATAKE Akira
金额：
$ 19.58万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

In this research we developed a high-frequency high-speed ultrasound system with 10MHz, 13MHz and 15-MHz electronic scan probes for the in vivo visualization of fine cardiovascular structures and measurement of their function. This system provided axial resolution of less than 0.20mm and lateral resolution of less than 0.25mm which could not have been achieved by conventional electronic scanners. Time resolution of our system was as high as 656 frames/sec. Moreover, we studied the usefulness of this system in the following 3 area ;1.Visualization and measurement of coronary artery : Human coronary arteries excised at autopsy were examined using a commercially available 7.5-MHz probe and our 10MHz-probe, and the results were compared with histological findings. When using the 10-MHz probe, the vessel structure was depicted more clearly and the lumen area and intima-media area could be more accurately measured than when using the 7.5-MHz probe.2. Evaluation of cardiovascular lesions in m … More ice : Apolipoprotein E-knockout mice have been shown to spontaneously develop atherosclerosis as seen in humans. Transthoracic echocardiography using our 13-MHz probe could detect atherosclerotic lesions and decreased distensibility of the ascending aorta as well as secondary changes in the left ventricular geometry in the apolipoprotein E-knockout mice.3. Measurements of medium-sized muscular arteries : We studied reproducibility of the ultrasound measurement of lumen diameter and intima-media thickness in the brachial and radial arteries using the 7.5-MHz, 10-MHz and 15-MHz probes. In every measurement the best reproducibility was obtained using 15-MHz probe. Percent flow-mediated dilatation of the brachial artery was also measured using the 3 probes and the reproducibility was also highest when using 15MHz probe.Thus, our new high-frequency ultrasound system will provide better structural information and detailed characterization of cardiovascular lesions in humans and experimental animals. Less

在这项研究中，我们开发了一种具有 10MHz、13MHz 和 15MHz 电子扫描探头的高频高速超声系统，用于精细心血管结构的体内可视化并测量其功能。该系统提供了小于0.20mm的轴向分辨率和小于0.25mm的横向分辨率，这是传统电子扫描仪无法实现的。我们系统的时间分辨率高达 656 帧/秒。此外，我们还研究了该系统在以下三个方面的实用性： 1.冠状动脉的可视化和测量：使用市售的 7.5 MHz 探头和我们的 10 MHz 探头检查尸检时切除的人类冠状动脉，并将结果与组织学结果进行比较。与使用7.5 MHz探头相比，使用10 MHz探头可以更清晰地描绘血管结构，并且可以更准确地测量管腔面积和内膜中层面积。2．冰中心血管病变的评估：载脂蛋白 E 敲除小鼠已被证明会自发地出现与人类相同的动脉粥样硬化。使用我们的13 MHz 探头进行的经胸超声心动图可以检测载脂蛋白E 敲除小鼠中的动脉粥样硬化病变、升主动脉扩张性的降低以及左心室几何结构的继发性变化。3．中等大小的肌性动脉的测量：我们研究了使用 7.5 MHz、10 MHz 和 15 MHz 探头超声测量肱动脉和桡动脉内腔直径和内膜中层厚度的再现性。在每次测量中，使用 15 MHz 探头都能获得最佳再现性。还使用 3 个探头测量了肱动脉血流介导的扩张百分比，并且使用 15MHz 探头时的重复性也最高。因此，我们的新型高频超声系统将提供人类和实验动物心血管病变的更好的结构信息和详细特征。较少的