Biomechanical Analysis of Aortic Aneurysm Failure to Find Out the Important Factors
主动脉瘤生物力学分析未能找出重要因素
基本信息
- 批准号:10480241
- 负责人:
- 金额:$ 8.38万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The aim of this project are to obtain mechanical properties of aneurysmal wall in vitro, to noninvasively measure the three dimensional shape of aneurysms for patients from MRI images, and to make models to predict the dangerous regions for aneurysm failure from the motion and stress analyses of aneurysmal wall. The following results were obtained.1. The specimen excised form the aneurysmal region of patients was used for the biaxial tensile testing. The machine was newly developed in our laboratory. The diseased specimen from aneurysm was stiffer than normal tissues. The specimens with the higher elastic moduli were the higher anisotropic mechanical properties.2. Three dimensional finite element model was successfully composed from MRI images for human thoracic aortas. In this model, the aortic wall was assumed to be thin membrane, isotropic, large linear deformation between diastolic and systolic pressures. The stress concentration was found in the frontal and dosal sides of aortic arch where aneurysm formation is frequently observed. Further, the location and shapes of the aneurysm had important and significant effects on the highest stress values and the stress distribution.3. The strain and stress were calculated around the aneurysm of patients by measuring the deformation of aortic wall in MRI images. The results showed us that the strain was large around the frontal walls of aortic arch in healthy normal person. In aneurysmal patients, the large deformation to the outer wall side around the aneurysms was observed.According to the present results, we will develop the new system to rapidly construct the finite element model from the MRI images and study more precise mechanical properties of aneurysmal walls.
本课题的目的是在体外获得动脉瘤壁的力学性能,从MRI图像中无创测量动脉瘤的三维形态,并根据动脉瘤壁的运动和应力分析建立预测动脉瘤破裂危险区域的模型。取得了以下研究成果:1.从患者的动脉瘤区域切取标本进行双向拉伸试验。这台机器是我们实验室新开发的。动脉瘤病变组织较正常组织僵硬。弹性模数越高的试件,其各向异性力学性能越高。成功地利用MRI图像建立了人体胸主动脉的三维有限元模型。在该模型中,假设主动脉壁为薄膜、各向同性、舒张压和收缩压之间的大的线性变形。应力集中在腹主动脉弓的前侧和背侧,是动脉瘤形成的高发部位。此外,动脉瘤的位置和形状对最高应力值和应力分布有重要且显著的影响。通过测量MRI图像中主动脉壁的变形量,计算动脉瘤周围的应变和应力。结果表明,健康正常人腹主动脉弓前壁附近应变较大。在动脉瘤患者中,观察到动脉瘤周围向外壁方向的大变形,根据目前的结果,我们将开发新的系统,从MRI图像快速构建有限元模型,并研究更精确的动脉瘤壁力学特性。
项目成果
期刊论文数量(43)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
吉田出: "MRI装置を用いた胸部大動脈瘤の3次元動態解析"脈管学. 38. 560 (1998)
Izuru Yoshida:“使用 MRI 装置对胸主动脉瘤进行三维动态分析”血管学 38. 560 (1998)。
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- 影响因子:0
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- 通讯作者:
I. Yoshida: "Three-dimensional analysis of dynamic behavior of thoracic aneurysm using MRI"J. Jap. Coll. Angiol.. 38. 560 (1998)
I.吉田:“利用MRI对胸动脉瘤动态行为进行三维分析”J。
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- 影响因子:0
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Matsumoto,T.: "Intramural strain analysis of atherosclerotic aorta of WHHL rabbit considering residual strain" Proc of the 5th JUSSC Conf on Biomech. 30-31 (1998)
Matsumoto,T.:“考虑残余应变的 WHHL 兔动脉粥样硬化主动脉壁内应变分析”第五届 JUSSC Biomech 会议的 Proc。
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- 影响因子:0
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加藤陽子: "半自動的色調判別に基づく生体組織標本の汎用画像解析法"ライフサポート. 11・4. 120-125 (2000)
加藤洋子:“基于半自动颜色辨别的生物组织样本的通用图像分析方法”Life Support 11・4(2000)。
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- 影响因子:0
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- 通讯作者:
高橋淳子: "モルモット動脈硬化モデルにおける血漿の脂質成分および自己蛍光の測定"脈管学. 38. 785-794 (1998)
Junko Takahashi:“豚鼠动脉粥样硬化模型中血浆脂质成分和自发荧光的测量”血管学 38. 785-794 (1998)。
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SATO Masaaki其他文献
Imaging the Neural Circuit Basis of Social Behavior: Insights from Mouse and Human Studies
成像社会行为的神经回路基础:来自小鼠和人类研究的见解
- DOI:
10.2176/nmc.ra.2020-0088 - 发表时间:
2020 - 期刊:
- 影响因子:1.9
- 作者:
MIURA Isamu;OVERTON Eric T.N.;NAKAI Nobuhiro;KAWAMATA Takakazu;SATO Masaaki;TAKUMI Toru - 通讯作者:
TAKUMI Toru
The sedative effect of the cholinergic transmission in the habenulo-interpedunclar pathway in social conflict
缰核脚间通路胆碱能传递在社会冲突中的镇静作用
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
MIURA Isamu;OVERTON Eric T.N.;NAKAI Nobuhiro;KAWAMATA Takakazu;SATO Masaaki;TAKUMI Toru;岡本仁 - 通讯作者:
岡本仁
SATO Masaaki的其他文献
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{{ truncateString('SATO Masaaki', 18)}}的其他基金
difficulty in generalization of tactile reading for persons with visual impairment and intellectual handicapped
触觉阅读对于视力障碍和智力障碍人士的推广存在困难
- 批准号:
17K04928 - 财政年份:2017
- 资助金额:
$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
In vivo two-photon imaging of learning-induced hippocampal neuronal circuit plasticity
学习诱导的海马神经元回路可塑性的体内双光子成像
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24700403 - 财政年份:2012
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$ 8.38万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Chemical Production and Modification of Fine ParticleUsing Ultrasonic Spray Method under Microwave Irradiation
微波辐射下超声喷雾法细颗粒的化学生产与改性
- 批准号:
23656412 - 财政年份:2011
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$ 8.38万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
In vivo chronic imaging of neuronal circuit plasticity using a genetically-encoded calcium sensor
使用基因编码钙传感器对神经元回路可塑性进行体内慢性成像
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21800091 - 财政年份:2009
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$ 8.38万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Study of Mechanisms of Cellular Mechanosensing
细胞机械传感机制研究
- 批准号:
20001007 - 财政年份:2008
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$ 8.38万 - 项目类别:
Grant-in-Aid for Specially Promoted Research
Study of roles of cytoskeletons in morphological responses of vascular endothelial cells to mechanical stimuli
细胞骨架在血管内皮细胞对机械刺激的形态反应中的作用研究
- 批准号:
17200030 - 财政年份:2005
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$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Mechanical dynamics of focal adhesions of vascular endothelial cells using nano-imaging
使用纳米成像研究血管内皮细胞粘着斑的机械动力学
- 批准号:
15086203 - 财政年份:2003
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$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Roles of Integrins of Endothelial Cells in Response to Mechanical Stimuli
内皮细胞整合素在机械刺激反应中的作用
- 批准号:
14208100 - 财政年份:2002
- 资助金额:
$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of Atomic Force Microscope System Combined with Confocal Laser Scanning Microscope to Simultaneously Measure Mechanical Stiffness and Observe Microstructure of Cultured Cells
开发原子力显微镜系统结合共焦激光扫描显微镜同时测量机械刚度并观察培养细胞的微观结构
- 批准号:
12480257 - 财政年份:2000
- 资助金额:
$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of Atomic Force Microscope System Combined with Confocal Laser Scanning Microscope to Simultaneously Measure Mechanical Stiffness and Observe Microstructure of Cultured Cells
开发原子力显微镜系统结合共焦激光扫描显微镜同时测量机械刚度并观察培养细胞的微观结构
- 批准号:
10558126 - 财政年份:1998
- 资助金额:
$ 8.38万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
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