Development of a Blood Pressure Control System for Wide Use

开发广泛使用的血压控制系统

• 批准号: 10555143
• 负责人: ARAKI Mituhiko
• 金额: $ 8.32万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10555143/
• 关键词: Blood pressure control; Hypotensive anesthesia; Trimethaphan; Risk control; Fuzzy inference; State-predictive control; ファジィ推論

In this research, we have improved our blood pressure control system for hypotensive anesthesia so that it can be used widely. To be concrete, we have made 1) improvement of risk control algorithm, 2) modification of the auto-tuning function for individual difference, and 3) modification of the system structure and interface. The obtained results are as follows.As new risk control functions, we added i) an algorithm for blood transfusion, i. e. transfusion of plasma protein fraction (PPF), concentrated red cell (CRC) and fresh frozen plasma (FFP), and ii) a function for determination of the maximal infusion rate of the hypotensive drug. By adding these functions, the safety of our system is improved.We modified the auto-tuning algorithm of the controller gain, which became inappropriate by the modification of risk control algorithm. By this modification, the controller gain can be changed small enough when the blood pressure is lower than the target blood pressure, and then the performance and the safety of our system are improved.A note-type personal computer is used to make the system smaller. Moreover, the interface for the command input is changed from keyboard to mouse in order to input command easily. Furthermore, a function of judging whether the input value is appropriate or not is added. By these modifications, our system can be easily used in usual operation rooms by medical doctors.Our modifications of the blood pressure control system achieve the purpose in safety and usability.

在本研究中，我们对低血压麻醉的血压控制系统进行了改进，使其可以广泛应用。具体来说，我们做了1)改进风险控制算法，2)修改个体差异的自调整功能，3)修改系统结构和接口。所得结果如下：作为新的风险控制功能，我们增加了1)输血算法，即输血血浆蛋白部分（PPF）、浓缩红细胞（CRC）和新鲜冷冻血浆（FFP），以及2)确定降压药物最大输注速率的函数。通过增加这些功能，提高了系统的安全性。对控制器增益的自整定算法进行了改进，该算法由于风险控制算法的修改而变得不合适。通过这种改进，当血压低于目标血压时，控制器增益可以改变得足够小，从而提高了系统的性能和安全性。使用笔记型个人电脑使系统更小。命令输入接口由键盘改为鼠标，方便用户输入命令。此外，还增加了判断输入值是否合适的功能。通过这些改进，我们的系统可以方便医生在普通手术室使用。我们对血压控制系统的改进在安全性和可用性上达到了目的。

项目成果

H.Onodera: "Clinical application of a blood pressure autoregulation system during hypotensive anesthesia"World Journal of Surgery. 23. 1258-1263 (1999)

H.Onodera：“血压自动调节系统在低血压麻醉期间的临床应用”《世界外科杂志》。

H.Onodera: "Clinical application of a blood pressure autoregulation system during hypotesive anesthesia"World Journal of Surgery. 23. 1258-1263 (1999)

H.Onodera：“血压自动调节系统在低血压麻醉期间的临床应用”世界外科杂志。

H.Onodera et al.: "Clinical application of a blood pressure autoregulation system during hypotensive anesthesia"World Journal of Surgery. 23. 1258-1263 (1999)

H.Onodera 等人：“低血压麻醉期间血压自动调节系统的临床应用”《世界外科杂志》。