Surgical treatment in macular diseases, criteria for indication by new modulity for examinations, and evaluation on outcome of treatment.

黄斑疾病的手术治疗、新检查模块的适应症标准以及治疗结果的评估。

• 批准号: 10557156
• 负责人: TAKAHASHI Kanji
• 金额: $ 5.18万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10557156/
• 关键词: multifocal posterior pigment epitheliopathy; bullous retinal detachment; uveal effusion syndrome; age-related macular degeneration; choroidal neovascularization; polypoidal choroidal vasculopathy; exudative age related macular degeneration; serous

In some of frequently occurred and severe macular diseases, pathophysiology, clinical features, criteria for diagnosis, indication for treatment, clinical course, and outcome were eveluated.1. Multifocal posterior pigment epitheliopathy (MPPE) This is a severe variant of central serous chorioretinopathy and its manifestation is bullous retinal detachment. Primary involvement of MPPE is in hyperpermeability of the choriocapillaris, and the retinal pigment epithelium is secondarily damaged, then lead to subretinal leakage from the choroid. Laser photocoagulation to the leakage sites is effecitve treatment.2. Uveal effusion syndrome Manifestation is a combination of bullous retinal detachment and annural choroidal detachment. There is no subretinal leakage. The sclera is thick and rigid. In the sclera, collagen fiber bundles are irragularly arranged, and proteoglycans are deposited in the matrix. Transscleral outflow of the intraocular fluid is impaired due to scleral abnormality. We conf … More irmed abnormality of the selera by CT, MRI, ultrasound, length of ocular axis. Subscleral sclerectomy is successful treatment. Among 19 eyes for 10 years, 6 eyes in type 1 ; nanophthalmic eye, 11 eyes in type 2 ; normal sized, abnormal sclera eye, 2 eyes in type 3 ; normal sized, normal sclera eyes.3. The second eye in unilateral exudative age-related macular degeneration. 170 eyes of the second eyes followed, choroidal neovascularizations (CNV) were developed in 12 eyes (7%), and accumulation of incidence were 0.6% by 1 year, 5.6% by 3 years, and 12.3% by 5 years with Kaplan-Meier life table analysis. Predisposing findings were mostly from serous RPE detachment, not from soft drusen.4. Polypoidal choroidal vasculopathy.Serous and hemorrhagic detachment of the retina and/or RPE in the posterior pole are common manifestation. ICG angiography revealed branching vascular network with polypoidal and aneurysmal dilatations. 35 eyes for 4 years were eveluated, and suggested as a variant of choroidal neovascularization beneath the RPE. Less

对一些常见的和严重的黄斑病变的病理生理、临床特征、诊断标准、治疗适应证、临床病程和预后进行评价.多灶性后部色素上皮病（MPPE）这是中心性浆液性脉络膜视网膜病变的一种严重变异，其表现为大泡性视网膜脱离。MPPE的主要表现是脉络膜毛细血管通透性增高，继发性视网膜色素上皮损伤，导致脉络膜下渗漏。对渗漏部位进行激光光凝是有效的治疗方法.葡萄膜渗出综合征表现为大泡性视网膜脱离和环状脉络膜脱离的结合。没有视网膜下渗漏。巩膜厚而硬。在巩膜中，胶原纤维束不规则地排列，并且蛋白多糖沉积在基质中。由于巩膜异常，眼内液体的经巩膜流出受损。我们确认 ...更多信息 CT、MRI、B超、眼轴长度等检查均显示鞍区异常。巩膜下巩膜切除术是成功的治疗方法。10年随访19眼，其中1型6眼，小眼2型11眼，正常大小巩膜异常3型2眼，正常大小巩膜正常2眼.单侧渗出性年龄相关性黄斑变性的第二只眼。第二眼随访170眼，发生脉络膜新生血管（CNV）12眼（7%），Kaplan-Meier寿命表分析显示，CNV累积发生率1年为0.6%，3年为5.6%，5年为12.3%。视网膜色素上皮脱离多为浆液性，而非软性玻璃膜.息肉状脉络膜血管病变：常见的临床表现为浆液性或出血性视网膜脱离和/或后极部的视网膜色素上皮。ICG血管造影显示分支血管网伴息肉样和囊样扩张。对35眼4年的随访结果进行了分析，认为这是视网膜色素上皮下脉络膜新生血管的一种变异。少

项目成果

Otsuji T, et al: "Optical coherence tomographic findings of idiopathic polypoidal choroidal vasculopathy"Ophthalmic Surgery and Lasers. 31. 210-214 (2000)

Otsuji T 等人：“特发性息肉状脉络膜血管病变的光学相干断层扫描结果”眼科手术和激光。

Uyama M, et al: "The second eye of Japanese patients with unilateral exudative age related macular degeneration."British Journal of Ophthalmology. 84. 1018-1023 (2000)

Uyama M等人：“日本单侧渗出性年龄相关性黄斑变性患者的第二只眼睛。”英国眼科杂志。

Uyama M, et al: "Indocyanine green angiography and pathophysiology of multifocal posterior pigment epitheliopathy."Retina. 19. 12-21 (1999)

Uyama M 等人：“吲哚菁绿血管造影和多灶性后色素上皮病的病理生理学。”视网膜。

Otsuji T, et al: "Optical coherence tomographic findings of idiopathic polypoidal choroidal vasculopathy."Ophthalmolmic Surgery and Lasers. 31. 210-214 (2000)

Otsuji T 等人：“特发性息肉状脉络膜血管病变的光学相干断层扫描结果。”眼科手术和激光。

宇山昌延: "Ureal effusion syndrome"Ophthalmology. 107. 441-449 (2000)

Masanobu Uyama：“尿素积液综合征”眼科。 107. 441-449 (2000)