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Research on the repartition of hyperlipidemia-inducing fat and accumulation- accelerating fat.

诱发高脂血症的脂肪重新分配和加速脂肪积累的研究。

基本信息

批准号：
10660260
负责人：
ITO Tatsumi
金额：
$ 2.3万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10660260/
关键词：
Beef Tallow Animal fats Vegetable oils Fatty acid composition Hyperlipidemia-inducing fat Accumulation-accelerating fat Lipid hydroperoxide β3-agonist 牛脂糞中の脂質

项目摘要

Absorption and repartition of dietary fats and fatty acid composition of lipids in the serum and in various tissues of SD rats were investigated. Pharmacological effect of β 3-agonists on the repartition of ingested lipids into the liver, muscle and abdominal cavity was also investigated. The amount of beef tallow remained in the feces was more than that of vegetable oils. Major fatty acids remained in the feces were palmitic, oleic and stearic acids. With regards to the fate of absorbed fats, the accumulation of olive oil into the liver and abdominal cavity was more that of beef tallow and the difference between the two lipids was statistically significant. Fatty acid composition of the accumulated lipid in perirenal fat (accumulated lipid in abdominal cavity) was quite similar to that of the every dietary fats examined. The composition of the accumulated lipid in the luver and in the muscle was also similar to that of the dietary fats. The accumulation of lipid in the tissues, especially of abdominal fat was decreased in the rats fed vegetable oils when BRL35, 135 was orally dosed at 0.5mg/kg diet/day for 6 weeks. Especially, the pro-drug was effective for reducing the accumulation of poly-unsaturated fatty acids. In the case of CGP12, 177, no significant effect was observed. Lipid hydroperoxide activity (LPO) of the accumulated lipids in the liver and abdominal cavity in the rats fed beef tallow was lower than that of the rats fed vegetable oils. However, LPO of feces of the rats fed beef tallow was slightly higher than that of the rats fed vegetable oils.

研究了SD大鼠饲料脂肪的吸收和再分配以及血清和各组织中脂质脂肪酸组成。我们还研究了β 3激动剂对摄入的脂质重新分配到肝脏、肌肉和腹腔的药理作用。牛油在粪便中的残留量大于植物油。粪便中残留的主要脂肪酸为棕榈酸、油酸和硬脂酸。至于被吸收的脂肪的命运，橄榄油在肝脏和腹腔的积累比牛油更多，两种脂质之间的差异具有统计学意义。肾周脂肪（腹腔脂肪）中积累的脂肪的脂肪酸组成与所检查的每种膳食脂肪非常相似。肝脏和肌肉中积累的脂质组成也与膳食脂肪相似。以0.5mg/kg日粮剂量口服BRL35, 135，连续6周，植物油喂养的大鼠组织脂质积累，特别是腹部脂肪的积累减少。特别是前药对减少多不饱和脂肪酸的积累有明显效果。在CGP12, 177的情况下，没有观察到显著的影响。饲喂牛油的大鼠肝脏和腹腔内积累的脂质氢过氧化活性（LPO）低于饲喂植物油的大鼠。而饲喂牛油的大鼠粪便的LPO略高于饲喂植物油的大鼠。