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The role of glycoxidative low-density lipoprotein. A novel modified low-density lipoprotein, in the formation of atherosccleotic lesions.

The role of glycoxidative low-density lipoprotein. A novel modified low-density lipoprotein, in the formation of atherosccleotic lesions.
糖氧化低密度脂蛋白的作用。
批准号:
10670183
负责人:
SAKATA Noriyuki
金额:
$1.86万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2001

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中文摘要
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英文摘要
N^ε-(carboxymethyl)lysine was formed in glycoxidative human serum albumin (HSA), butnot in oxidative HSA.Glycoxidation and oxidation of HSA significantly decreased the contents of free thiol groups.The antioxidant activity of glycoxidative HSA to LDL-oxidation was the lowest among various modified HSAS.Oxidative HSA showed a moderate decrease in antioxidant activity.
期刊论文(33)
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会议论文
Meng J.,Sakata N.,Takebayashi S.: "Increased glycoxidation and lipoperoxidation in the collagen of the myocardium in hemodialysis patients."Cardiovascular Research. 47. 306-313 (2000)
Meng J.,Sakata N.,Takebayashi S.:“血液透析患者心肌胶原中的糖氧化和脂过氧化增加。”心血管研究。
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通讯作者:
Sakata N.,Sasatomi Y.,Ando S.,Meng J.,Imanaga Y., et al.: "Causal relationship between conformational change and inhibition of domain functions of glycoxidative fibronectin."Connective Tissue Research. 41・2. 117-129 (2000)
Sakata N.、Sasatomi Y.、Ando S.、Meng J.、Imanaga Y. 等:“糖氧化纤连蛋白结构域功能抑制之间的因果关系”41・2。 129(2000)
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通讯作者:
坂田則行,今永至信,孟晶,竹林茂夫: "糖尿病と動脈硬化.病理学的特徴-ことに糖酸化と脂質過酸化を中心に-"動脈硬化. 27・9,10. 267-271 (2000)
Noriyuki Sakata、Toshinori Imanaga、Jing men、Shigeo Takebayashi:“糖尿病和动脉硬化。病理学特征 - 关注糖氧化和脂质过氧化” 动脉硬化 27・9,10。
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通讯作者:
Sakata, N: "Glycoxidation and lipid peroxidation of low-density lipoprotein can syriergistically enhance atherogenesis."Cardiovasc. Res.. 49. 466-475 (2001)
Sakata,N:“低密度脂蛋白的糖氧化和脂质过氧化可以协同增强动脉粥样硬化形成。”心血管。
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33
    Role of Na+/Ca2+ exchanger in the mechanism of aortic dissection
    • 批准号:
      22590325
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2010
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    Role of sodium/calcium ion exchanger expressed in macrophages in atherogenesis
    • 批准号:
      19590372
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    Mechanism of myocardial tissue damage in patients with diabetes, chronic renal failure and hemodialysis
    • 批准号:
      14570171
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    海外基金