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Role of sodium/calcium ion exchanger expressed in macrophages in atherogenesis

Role of sodium/calcium ion exchanger expressed in macrophages in atherogenesis
巨噬细胞表达的钠/钙离子交换剂在动脉粥样硬化形成中的作用
批准号:
19590372
负责人:
SAKATA Noriyuki
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
To clarify the mechanism which is responsible for the plaquerupture, we investigated the expression of sodium/calcium ion exchanger and matrix metalloproteinase and the stress/strain distribution in the human carotid arterial wall. Activated macrophages in fibrous cap expressed sodium/calcium ion exchanger-1 and matrix metalloproteinases-2 and 9 in atherosclerotic plaques. Therefore, these cells may contribute to the thinning and disruption of fibrous cap in the plaque. In addition, the concentration of the maximal principal stress is likely to trigger the plaque rupture.
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Crystalization and preliminary X-ray crystallographic analysis of Ca2+-free primary Ca2+-sensor of Na+/Ca2+ exchanger.
Na /Ca2 交换器的无 Ca2 主 Ca2 传感器的结晶和初步 X 射线晶体分析。
DOI: --
发表时间: 2008
期刊: Acta Crystallogr Sect F Struct Biol Cryst Commun 64
影响因子: --
作者: [Mima M, Kawai C, Paku K, Tomoo K, Ishida T, Sugiyama S, Matsumura H, Kitatani T, Yoshikawa HY, Maki S, Adachi H, Takano K, Murakami S, Inoue T, Mori Y, Kita S, Iwamoto T.]
通讯作者: Iwamoto T.
Immunological detection of N^ω-(carboxymethyl)arginine by a specific antibody.
通过特异性抗体对 N^ω-(羧甲基)精氨酸进行免疫学检测。
DOI: --
发表时间: 2008
期刊: Ann. N. Y. Acad. Sci.
影响因子: --
作者: [伊藤健二, 兼岡秀俊, 坂田則行, 川上豪仁, 上杉憲子, 森超夫, 冷牟田浩司, 斉藤喬雄, Sakata Noriyuki, Mera Katsumi]
通讯作者: Mera Katsumi
頸部内頚動脈偽閉塞症の病理組織学的検討
颈部颈内动脉假性闭塞的组织病理学检查
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yamada H, Yuri K, Sakata N, 坂田則行, 山田宏, 平田陽子]
通讯作者: 平田陽子
Immunological detection of N omega-(Carboxyl)arginine by a specific antibody
通过特异性抗体对 N omega-(羧基)精氨酸进行免疫学检测
DOI: --
发表时间: 2008
期刊: Ann N Y Acad Sci. 1126
影响因子: --
作者: [Mera K, Fujiwara Y, Otaguri M, Sakata N, Nagai R]
通讯作者: Nagai R
33
    Role of Na+/Ca2+ exchanger in the mechanism of aortic dissection
    • 批准号:
      22590325
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.5万
    • 财政年份:
      2010
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    Mechanism of myocardial tissue damage in patients with diabetes, chronic renal failure and hemodialysis
    • 批准号:
      14570171
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2002
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    The role of glycoxidative low-density lipoprotein. A novel modified low-density lipoprotein, in the formation of atherosccleotic lesions.
    • 批准号:
      10670183
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.86万
    • 财政年份:
      1998
    • 负责人:
      SAKATA Noriyuki
    • 依托单位:
    海外基金