エタノール代謝物蛋白結合体の諸臓器組織、および機能におよぼす影響

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We gave mash feed (CE-7, CREA Japan) and a 16% ethanol solution (rice wine) ad libitum in place of drinking water to the ethanol group. The control group received an isocaloric diet with a granulated sugar solution, instead of ethanol, and mash feed in the same amount as the ethanol group )nutrient-matched isocaloric diet).The ethanol group animals excreted more calcium in their urine than the controls (p<0.05), but ethanol intake had no effection the serum level of calcium. The kidney and blood bound ethanol levels of the ethanol group were higher than the controls (p<0.01, p<0.01).No evidence of hepatic pathology, fatty change or necrosis was observed either group. The ethanol group had significantly more instances of basophilic renal tubules, swelling of tubular epithelial cells and PAS positive glomerular deposits than the control group.Soft radiographs of the ethanol group showed significantly more bone atrophy and thinning of both the bone trabeculae and bone cortex than in the control group.Although ethanol consumption was associated with a significant increase in urinary calcium excretion, it decreased renal tubular resorption.After one week intake, the ethanol group had a significantly enhanced mitogenic response to ConA, compared with the control group.After 3 months intake, the ethanol group had a significantly enhanced mitogenic response to LPS, compared with the control group.Bound ethanol in the kidneys and blood was observed, but IgA deposition was not seen in immunohistochemical analysis of the kidneysThese data suggest that bound ethanol can lead to immune enhancement.Finally, the mortality rate of after 29 months was significantly lower in the ethanol group (p<0.05).Ethanol intake appears accelerate antibody production, improving immune response to infection and food antigens, thereby resulting in lifespan.