エタノール代謝物蛋白結合体の諸臓器組織、および機能におよぼす影響

我们给乙醇组随意提供饲料（CE-7, CREA Japan）和16%乙醇溶液（米酒）代替饮用水。对照组饲喂等热量饲粮，用白砂糖溶液代替乙醇，并饲喂与乙醇组相同量的糊状饲料（营养匹配的等热量饲粮）。乙醇组动物尿液中钙排泄量高于对照组（p<0.05），但乙醇摄入对血清钙水平无影响。乙醇组大鼠肾和血结合乙醇水平均高于对照组（p<0.01, p<0.01）。两组均未见肝脏病理、脂肪改变或坏死。与对照组相比，乙醇组有更多的嗜碱性肾小管、小管上皮细胞肿胀和PAS阳性肾小球沉积。软性x线片显示，与对照组相比，乙醇组的骨萎缩和骨小梁和骨皮质均变薄。尽管乙醇消耗与尿钙排泄显著增加有关，但它减少了肾小管钙的吸收。摄入一周后，与对照组相比，乙醇组对ConA的有丝分裂反应显著增强。摄入3个月后，与对照组相比，乙醇组对LPS的有丝分裂反应显著增强。在肾脏和血液中观察到结合乙醇，但在肾脏免疫组织化学分析中未见IgA沉积，这些数据表明结合乙醇可导致免疫增强。最后，乙醇组29个月后的死亡率显著低于对照组（p<0.05）。乙醇摄入似乎能加速抗体的产生，提高对感染和食物抗原的免疫反应，从而延长寿命。

We gave mash feed (CE-7, CREA Japan) and a 16% ethanol solution (rice wine) ad libitum in place of drinking water to the ethanol group. The control group received an isocaloric diet with a granulated sugar solution, instead of ethanol, and mash feed in the same amount as the ethanol group )nutrient-matched isocaloric diet).The ethanol group animals excreted more calcium in their urine than the controls (p<0.05), but ethanol intake had no effection the serum level of calcium. The kidney and blood bound ethanol levels of the ethanol group were higher than the controls (p<0.01, p<0.01).No evidence of hepatic pathology, fatty change or necrosis was observed either group. The ethanol group had significantly more instances of basophilic renal tubules, swelling of tubular epithelial cells and PAS positive glomerular deposits than the control group.Soft radiographs of the ethanol group showed significantly more bone atrophy and thinning of both the bone trabeculae and bone cortex than in the control group.Although ethanol consumption was associated with a significant increase in urinary calcium excretion, it decreased renal tubular resorption.After one week intake, the ethanol group had a significantly enhanced mitogenic response to ConA, compared with the control group.After 3 months intake, the ethanol group had a significantly enhanced mitogenic response to LPS, compared with the control group.Bound ethanol in the kidneys and blood was observed, but IgA deposition was not seen in immunohistochemical analysis of the kidneysThese data suggest that bound ethanol can lead to immune enhancement.Finally, the mortality rate of after 29 months was significantly lower in the ethanol group (p<0.05).Ethanol intake appears accelerate antibody production, improving immune response to infection and food antigens, thereby resulting in lifespan.