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エタノール代謝物蛋白結合体の諸臓器組織、および機能におよぼす影響

乙醇代谢蛋白复合物对各器官组织及功能的影响

基本信息

批准号：
10670325
负责人：
IMAI Tsunehiko
金额：
$ 1.09万
依托单位：
Toho University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

We gave mash feed (CE-7, CREA Japan) and a 16% ethanol solution (rice wine) ad libitum in place of drinking water to the ethanol group. The control group received an isocaloric diet with a granulated sugar solution, instead of ethanol, and mash feed in the same amount as the ethanol group )nutrient-matched isocaloric diet).The ethanol group animals excreted more calcium in their urine than the controls (p<0.05), but ethanol intake had no effection the serum level of calcium. The kidney and blood bound ethanol levels of the ethanol group were higher than the controls (p<0.01, p<0.01).No evidence of hepatic pathology, fatty change or necrosis was observed either group. The ethanol group had significantly more instances of basophilic renal tubules, swelling of tubular epithelial cells and PAS positive glomerular deposits than the control group.Soft radiographs of the ethanol group showed significantly more bone atrophy and thinning of both the bone trabeculae and bone cortex than in the control group.Although ethanol consumption was associated with a significant increase in urinary calcium excretion, it decreased renal tubular resorption.After one week intake, the ethanol group had a significantly enhanced mitogenic response to ConA, compared with the control group.After 3 months intake, the ethanol group had a significantly enhanced mitogenic response to LPS, compared with the control group.Bound ethanol in the kidneys and blood was observed, but IgA deposition was not seen in immunohistochemical analysis of the kidneysThese data suggest that bound ethanol can lead to immune enhancement.Finally, the mortality rate of after 29 months was significantly lower in the ethanol group (p<0.05).Ethanol intake appears accelerate antibody production, improving immune response to infection and food antigens, thereby resulting in lifespan.

我们给醪饲料（CE-7，CREA日本）和16%的乙醇溶液（米酒）自由采食，以代替乙醇组的饮用水。对照组用砂糖溶液代替乙醇等热量饲料，酒精组动物尿钙排泄量显著高于对照组（p<0.05），但对血清钙水平无影响。乙醇组大鼠肾脏和血液中乙醇含量均高于对照组（P<0.01，P<0.01），两组均未观察到肝脏病理改变、脂肪变性和坏死。酒精组肾小管嗜碱性、肾小管上皮细胞肿胀和PAS阳性肾小球沉积的例数明显多于对照组，软X线片显示酒精组骨萎缩、骨小梁和骨皮质变薄的例数明显多于对照组，尽管酒精摄入量与尿钙排泄量显著增加有关，结果表明，乙醇组大鼠肾脏和血液中结合乙醇浓度明显高于对照组，肾脏和血液中结合乙醇浓度明显高于对照组。免疫组化结果显示，乙醇组大鼠肾脏中未见伊加沉积，提示乙醇结合可导致免疫增强，29个月后死亡率显著低于对照组（p<0.05）.酒精摄入似乎加速抗体产生，改善对感染和食物抗原的免疫反应，从而延长寿命。