Study on nested-case-control in serum-cohort of atomic bomb survivors in Hiroshima City.

广岛市原子弹幸存者血清队列巢式病例对照研究。

• 批准号: 10670352
• 负责人: HAYAKAWA Norihiko
• 金额: $ 1.98万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670352/
• 关键词: Nested case control syudy; serum cohort; conditional proportional bazard-risk; cancer; 保存凍結血清; がんマーカー; 肺がん; 大腸がん; 胃がん; 保存凍血血清; ネステッド・ケース・コントロール研究

Study on the mechanisms of cancer-causing using the data base of Atomic bomb survivors of Hiroshirma University and serum-cohort by nested case control methods. Gathering of life style, past histry of diseases, condition of health by quetionair. We fund 1,523 persons of the begining of cancer and death of cancer by record-linkage of together tumor registry (Tissue registry of Hiroshima Prefecture and cancer registry of Hiroshima city) and Atomic bomb survivors data base. Stomach cancer were 15 cases (male 6, female 9), 57controls (male 21, female 36). Colon cancer were 19 cases (male 5, female 14), 71 controls (male 18, female 53). Lung cancer were 6 cases (male 3, female 3), 22 controls (male 10, female 12). For defects data of lyfe style, past hystry of diseases, we could not analyze the nested case control by the conditional hazard model. We could analyze the several cancer markers by the hazard model. CEA and Helicobacter pylory were the significant risk factors of stomach and colon cancer.

利用广岛大学原子弹幸存者数据库和血清队列，采用巢式病例对照方法研究致癌机制。通过问卷收集生活方式、既往疾病史、健康状况。通过肿瘤登记处（广岛县组织登记处和广岛市癌症登记处）和原子弹幸存者数据库的记录链接，资助1,523名癌症发生和癌症死亡的人。胃癌组15例（男6例，女9例），对照组57例（男21例，女36例）。结肠癌组19例（男5例，女14例），对照71例（男18例，女53例）。肺癌组6例（男3例，女3例），对照22例（男10例，女12例）。对于lyfe风格的缺陷数据、既往疾病史，我们无法通过条件风险模型来分析嵌套病例控制。我们可以通过风险模型分析几种癌症标志物。 CEA和幽门螺杆菌是胃癌和结肠癌的重要危险因素。