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Quantitative Tissue Characterization of Valvular Disease Based Upon Acoustic Properties Measured by High-frequency Ultrasound

基于高频超声测量的声学特性的瓣膜疾病的定量组织表征

基本信息

批准号：
10670664
负责人：
SAKAMOTO Seiji
金额：
$ 1.09万
依托单位：
Kagawa Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

The purpose of the present study was to measure tissue sound speed and ultrasonic attenuation of cardiac valve using acoustic microscopy with high frequency ultrasound. Myocardial and valvular tissue density positively correlated with the tissue sound speed measured by acoustic microscopy. Therefore, according to the equation K=ρ c^2, where K is the bulk modulus, ρ is the density, and c is the sound speed of tissue, myocardial and valvular tissue sound speed data enables us to evaluate tissue elasticity without measuring tissue density directly. In order to assess die physical properties of mitral valve tissue by evaluating the sound speed of the mitral valve tissue in cardiac amyloidosis, mitral valve specimens were obtained at autopsy from 20 control subjects without cardiovascular disease and from 20 patients with cardiac amyloidosis. The tissue sound speed was measured using acoustic microscopy. The patients with cardiac amyloidosis showing moderate mitral regurgitation demonstrated the greater reduction in the tissue sound speed than the patients with cardiac amyloidosis showing mild mitral regurgitation. The data suggest that the changes in physical properties of the MV tissue may be one of causes of mitral regurgitation in cardiac amyloidosis. Thus, tissue sound speed of cardiac valve measured by acoustic microscopy provides information regarding quantitative tissue characterization and pathophysiology in valvular disease.

本研究的目的是利用高频超声声显微镜测量心脏瓣膜的组织声速和超声衰减。心肌和瓣膜组织密度与声学显微镜测量的组织声速呈正相关。因此，根据公式K=ρ c^2，其中K是体积模量，ρ是密度，c是组织声速，心肌和瓣膜组织声速数据使我们能够在不直接测量组织密度的情况下评估组织弹性。为了通过评估心脏淀粉样变性二尖瓣组织的声速来评估二尖瓣组织的物理性质，在尸检时获得了20例无心血管疾病的对照受试者和20例心脏淀粉样变性患者的二尖瓣标本。使用声学显微镜测量组织声速。显示中度二尖瓣返流的心脏淀粉样变性患者比显示轻度二尖瓣返流的心脏淀粉样变性患者表现出更大的组织声速降低。提示二尖瓣组织物理性质的改变可能是淀粉样变二尖瓣返流的原因之一。因此，通过声学显微镜测量心脏瓣膜的组织声速提供了关于瓣膜疾病的定量组织表征和病理生理学的信息。