Experimental Study on Stereotactic Radiotherapy and Ir-192 High Dose Rate Brachytherapy of Liver Cancer

肝癌立体定向放射治疗和Ir-192高剂量率近距离治疗的实验研究

• 批准号: 10670875
• 负责人: OGUCHI Manabu
• 金额: $ 0.96万
• 依托单位: KANAZAWA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670875/
• 关键词: stereotactic radiotherapy; Ir-192 high dose rate brachytherapy; rabbit liver; VX2 tumor; 192Ir高線量率照射; 日本白色家兎; VX2腫瘍; 健常ラット

To evaluate effect of stereotactic radiotherapy and Ir-192 high dose rate(HDR) brachytherapy on liver cancer, experimental study was performedusing normal liver and transplanted VX2 tumor in the rabbits. A dose of 40Gy at a distance 5mm from Ir-192 source was given to normal liver of rabbits. Histological findings of the liver 5 days after interstitial brachytherapy showed necrosis or apoptosis of hepatic cells and foreign body granuloma with hemorrhage. Hepatic cells at long distance from the source were essentially normal. VX2 tumors transplanted in the muscle of hind leg were irradiated by stereotactic radiosurgery system. A dose of 40 Gy was administrated to the whole tumor tissue. Histological findings of the tumor 5 days after stereotactic radiotherapy showed necrosis and apoptosis of almost all tumor cells. VX2 tumors were also irradiated by Ir-192 HDR interstitial brachytherapy. A dose of 40Gy at a distance 5mm from the source was given to VX2 tumors. Histological findings of the tumor 5days after brachytherapy showed necrosis or apoptosis of tumor cells near the source. Apoptosis and necrosis of hepatic cells and VX2 tumor cells were thought to be radiation effects. Therapeutic effect of stereotactic radiotheapy on VX2 tumors was superior to that of Ir-192 HDR brachytherapy, because of the difference of dose distributions.Streotactic radiotherapy may be a promising therapeutic tool for liver cancer. High dose administration to tumor at one time can be achieved by stereotactic radiotherapy without invasiveness.

为评价立体定向放射治疗和Ir-192高剂量率（HDR）后装治疗肝癌的疗效，对兔正常肝和移植性VX 2肝癌进行了实验研究。在离~（192）Ir源5 mm处对家兔正常肝脏照射40 Gy。间质内放疗后5天的肝脏组织学检查结果显示肝细胞坏死或凋亡，异物肉芽肿伴出血。远距离肝细胞基本正常。采用立体定向放射外科系统对移植于后肢肌肉内的VX 2肿瘤进行放射治疗。肿瘤全组织剂量为40戈伊。立体定向放射治疗后5天的肿瘤组织学结果显示几乎所有的肿瘤细胞坏死和凋亡。还通过Ir-192 HDR间质近距离放射治疗照射VX 2肿瘤。VX_2肿瘤在距放射源5 mm处接受40 Gy的剂量。近距离放射治疗后5天，肿瘤组织学检查显示近源区肿瘤细胞坏死或凋亡。肝细胞和VX 2肿瘤细胞的凋亡和坏死被认为是辐射效应。立体定向放射治疗对VX 2肝癌的疗效上级Ir-192 HDR近距离放射治疗，这是由于立体定向放射治疗剂量分布的差异，立体定向放射治疗可能是一种有前途的肝癌治疗手段。立体定向放射治疗可实现肿瘤一次性高剂量给药，无创。