Thestructure of brain electric field on schizophrnia

关于精神分裂症患者的脑电活动已有许多神经心理学研究，但遗憾的是，其结果仍然难以捉摸。然后，我们检测了未经治疗的精神分裂症患者的脑电微态特征。它们是大脑功能信息处理的最小电单位。受试者为20例未经治疗的精神分裂症患者，年龄和性别匹配的正常对照参与本研究。我们记录了19个部位闭着眼睛和视觉上无伪影的头皮脑电，作为每个受试者的代表性数据。本研究的分析方法是微态建模与分析(EMMA)和低分辨率电磁层析(LORETA)。EMMA是从一系列与心理状态特征相关的脑电活动中确定最佳脑电地形图及其个数的方法。LORETA是一种在大脑电场中定位电源的方法。结果从精神分裂症患者和对照组中提取了三个模型图(MAP1、MAP2、MAP3)。精神分裂症患者MAPNO2的贡献和出现明显不同于正常对照组。Loreta成像显示MAP2电流密度高分布于左侧颞叶上回周围，提示精神分裂症患者存在神经回路异常。

There are many neuropsychological studies on the brain electric activity of schizophrenics, unfortunately it still remains elusive results. Then, we examined the feature of the EEG microstates of untreated schizophrenics. They are the minimum electric units of information processing of the brain function. Subjects were 20 untreated schizophrenics and age-and-sex matched normal controls participated in this study. We have recorded EEG from 19 sites on the scalp with closed eyes and visually free from artifacts were chosen to be the representative data of each subject. Methods of analysis in this study were Microstates Modeling and Analysis (EMMA) and Low Resolution Electromagnetic Tomography (LORETA). EMMA is a method to decide the optimum brain electric potential maps and their number from a series of brain electric activity that relate to the characteristics of mental state. LORETA is a method to localize the electrical sources in the brain electric field. As a result, three model maps (Map1, 2, 3) were extracted from schizophrenics and controls. Contribution and occurrence of Map No2 were clearly different in schizophrenics from in controls. The current density of Map No2 was highly distributed around left superior temporal gyrus with LORETA imaging which indicated abnormal neural circuitry in schizophrenia.