The corpus callosum in obsessive-compulsive disorder : a diffusion tensor imaging study

强迫症中的胼胝体：扩散张量成像研究

• 批准号: 16591173
• 负责人: KINOSHITA Toshihiko
• 金额: $ 2.12万
• 依托单位: Kansai Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16591173/
• 关键词: brain・nerve; cranial nerve disease; 強迫性障害; MRI; 拡散テンソル; 線維連絡; 白質

Purpose:To prospectively examine white matter microstructural abnormalities in the corpus callosum (CC) of OCD patients, as compared with controls, and to investigate the relationship between DTI measures of the CC region and clinical symptoms in OCD.Materials and Methods :Institutional review board approval was obtained, and each participant (or parents) provided written informed consent. 16 patients with OCD (7 men, 9 women; mean±SD age, 28.7±9.8) and matched control subjects (7 men, 9 women; mean±SD age, 29.9±9.0). Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the five subdivisions of the CC. Paired t test was used to compare MD or FA of CC regions from patients with OCD and controls.Results :There were no significant differences (rostrum, p=0.15; genu, p=0.88; rostral body, p=0.12; isthmus, p=0.77; splenium, p=0.88) of MD between patients with OCD and healthy volunteers. A significant reduction in FA was found in the rostrum of the CC of patients with OCD compared with that of controls (P < 0.001). Higher FA only in the rostrum correlated significantly with lower Y-BOCS scores (r=-0.72, p=0.002).Conclusions :Our results support the widely held view that the orbital prefrontal region is involved in the pathophysiology of OCD and also imply involvement of the orbitofrontal circuit in symptom severity in OCD patients.

目的：前瞻性地检查强迫症患者胼胝体（CC）的白质微结构异常，并与对照组相比，并调查 CC 区域的 DTI 测量值与强迫症患者临床症状之间的关系。 材料和方法：获得机构审查委员会的批准，每位参与者（或家长）提供书面知情同意书。 16 名强迫症患者（7 名男性，9 名女性；平均±SD 年龄，28.7±9.8）和匹配的对照受试者（7 名男性，9 名女性；平均±SD 年龄，29.9±9.0）。在 CC 的五个细分中测量平均扩散率 (MD) 和分数各向异性 (FA)。采用配对 t 检验比较 OCD 患者和对照组 CC 区的 MD 或 FA。结果：OCD 患者与健康志愿者之间的 MD 没有显着差异（吻部，p=0.15；膝部，p=0.88；吻部，p=0.12；峡部，p=0.77；压部，p=0.88）。与对照组相比，强迫症患者的 CC 喙部 FA 显着减少（P < 0.001）。仅在讲台上较高的 FA 与较低的 Y-BOCS 评分显着相关（r=-0.72，p=0.002）。结论：我们的结果支持了广泛持有的观点，即眶前额叶区域参与了强迫症的病理生理学，并且也意味着眶额环路参与了强迫症患者症状的严重程度。

项目成果

1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER A DIFFUSION TENSOR IMAGING STUDY

1 神经精神病学系；

• 发表时间: 2007
• 作者: Y. Saito^1;K. Nobuhara^1;G. Okugawa^1;K. Takase^1;T. Sugimoto^1;K. Ikeda^2;S. Sawada^2;T. Kinoshita^1
• 通讯作者: T. Kinoshita^1

1 Department of Neuropsychiatry ; 2 Department of Radiology, Kansai Medical University, Osaka, JapanWHITE MATTER ABNORMALITIES IN OBSESSIVE-COMPULSIVE DISORDER

1 神经精神病学系；

• 发表时间: 2006
• 作者: Y. Saito^1;K. Nobuhara^1;G. Okugawa^1;K. Takase^1;T. Sugimoto^1;K. Ikeda^2;S. Sawada^2;T. Kinoshita^1
• 通讯作者: T. Kinoshita^1

White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study.

• DOI: 10.1001/archpsyc.62.7.782
• 发表时间: 2005-07
• 期刊: Archives of general psychiatry
• 作者: P. Szeszko;B. Ardekani;M. Ashtari;A. Malhotra;D. Robinson;R. Bilder;K. Lim

強迫の診立てと治療I 強迫性障害における脳画像研究

强迫症的诊治一：强迫症的脑影像学研究

• 发表时间: 2007
• 期刊: 精神科治療学 22
• 作者: Saito Y;Nobuhara K;Okugawa G;Takase K;Sugimoto T;Horiuchi M;Ueno C;Maehara M;Omura N;Kurokawa H;Ikeda K;Tanigawa N;Sawada S;Kinoshita T.;齋藤 幸子
• 通讯作者: 齋藤 幸子

THE CORPUS CALLOSUM IN OBSESSIVE-COMPULSIVE DISORDER:A DIFFUSION TENSOR IMAGING STUDY

强迫症中的胼胝体：弥散张量成像研究

• 发表时间: 2006
• 作者: Y. Saito^1;K. Nobuhara^1;G. Okugawa^1;K. Takase^1;T. Sugimoto^1;K. Ikeda^2;S. Sawada^2;T. Kinoshita^1;Y.Saito
• 通讯作者: Y.Saito