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Abnormalities in oxygen metabolism during sepsis

Abnormalities in oxygen metabolism during sepsis
脓毒症期间氧代谢异常
批准号:
10671114
负责人:
KUWAGATA Yasuyuki
金额:
$2.05万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 2000

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英文摘要
When systemic oxygen delivery (DO_2)is reduced, oxygen consumption(VO_2)is maintained until a critical level is reached (DO_2crit). Sepsis is thought to shift DO_2crit to the right and lengthen the supply-dependent portion. We tested the effect of interleukin(IL)-1β, which is one of the key cytokines related to sepsis, on the VO_2/DO_2 relationship. Rabbits were subjected to stepwise cardiac tamponade to reduce DO_2 by inflating a handmade balloon placed into the pericardial sac. Seven rabbits were given 10 μg/kg of IL-1β intravenously prior to the graded cardiac tamponade. The remainder(n = 8)received saline alone(control group). The VO_2/DO_2 relationship was analyzed by the dual-line method. IL-1β significantly decreased mean arterial pressure(65±11 mmHg from baseline 85±7 mmHg)without altering cardiac output. The IL-1β group showed significantly steeper supply-independent line slopes than did the control group(0.19±0.02 vs.0.11 ±0.02, respectively). The IL-1β group also showed grea … More ter PO_2 and plasma lactate levels in the portal vein than did the control group. These results indicate that IL-1β impairs systemic oxygen uptake even before VO_2 becomes supply-dependent, presumably due to maldistribution of the blood flow including the splanchnic circulation. Subsequently, we investigated the inotropic effect of dopamine on the VO_2/DO_2 abnormality induced by IL-1β. Twelve rabbits were divided into two groups(n = 6, each)and given 10 μg/kg of IL-1β or saline(control group)intravenously. After baseline measurements, dopamine was continuously infused at a rate of 20 μg/kg/min throughout the study in both groups. Dopamine failed to restore IL-1β-induced decrease in mean arterial pressure(72±9 mmHg)to baseline level(91±5 mmHg). Dopamine increased cardiac output ant DO_2, but did not affect VO_2. The IL-1β group showed significant greater slopes of the supply-independent line than the control group (IL-1β : y = 0.14 x + 6.3, control : y = 0.06 x + 8.6)during the stepwise decrease in DO_2. These results indicate that the continuous infusion of dopamine at 20 μg/kg/min increased DO_2, but failed either to improve the vasomotor disturbance or to restore the VO_2/DO_2 abnormality induced by IL-1β. Less
期刊论文(5)
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会议论文
Kuwagata Y: "Interleukin-1β alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line"Shock. 14. 193-9 (2000)
Kuwagata Y:“Interleukin-1β 通过增加供应独立线的斜率来改变兔子的氧气输送-氧气消耗关系”Shock 14. 193-9 (2000)。
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通讯作者:
Oda J: "Mild hypothermia alters the O_2 consumption/delivery relationship by decreasing the slope of the supply-dependent line."Crit Care Med. (in press.).
Oda J:“轻度低温通过降低供应依赖线的斜率来改变 O_2 消耗/输送关系。”Crit Care Med。
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通讯作者:
Yasuyuki Kuwagata et al.: "Interleukin-1β alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line"Shock. (in press).
Yasuyuki Kuwagata 等人:“Interleukin-1β 通过增加供应独立线的斜率来改变兔子的氧气输送-氧气消耗关系”休克(正在出版)。
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通讯作者:
Kuwagata Y: "Interluekin-1β alters the oxygen delivery-oxygen consumption relationship in rabbits by increasing the slope of the supply-independent line."Shock. 14. 193-9 (2000)
Kuwagata Y:“Interluekin-1β 通过增加供应独立线的斜率来改变兔子的氧气输送-氧气消耗关系。”Shock 14. 193-9 (2000)
DOI: --
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Development of a novel strategy of circulatory management of septic shock with modulation of splanchnic hemodynamics.
  • 批准号:
    20K09317
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.75万
  • 财政年份:
    2020
  • 负责人:
    KUWAGATA Yasuyuki
  • 依托单位:
Development of a novel strategy of circulatory management of septic shock with modulation of beta adrevergic stimulation.
  • 批准号:
    17K11599
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2017
  • 负责人:
    KUWAGATA Yasuyuki
  • 依托单位:
Understanding an impact of tissue wall stress to develop a novel strategy of circulatory management
  • 批准号:
    25670761
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2013
  • 负责人:
    KUWAGATA Yasuyuki
  • 依托单位:
Mechanisms of organ failure and abnormal oxygen metabolism during sepsis
  • 批准号:
    16390515
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $9.09万
  • 财政年份:
    2004
  • 负责人:
    KUWAGATA Yasuyuki
  • 依托单位:
海外基金