Research on therapy to promote pulmonary vascular maturation for the treatment of congenital heart disease

促进肺血管成熟治疗先天性心脏病的研究

基本信息

  • 批准号:
    10671236
  • 负责人:
  • 金额:
    $ 1.6万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1998
  • 资助国家:
    日本
  • 起止时间:
    1998 至 1999
  • 项目状态:
    已结题

项目摘要

[Aim] To clarify the role of heparin in pulmonary vascular proliferation and develop the treatment to promote the pulmonary vascular maturation. [Method and Results] Newborn rabbits were given heparin (heparin group), protamine (protamine group) or saline (control group) subcutaneously for 14 days. The density of pulmonary capillaries measured using computer analysis system was highest in the heparin group, next in the control group and lowest in the protamine grooup. The amount of VEGF assessed using immunostain was high in the order : heparin group, control group and protamine group. Rght ventricular pressure was lowest in the heparin group, intermediate in saline group and highest in protamine group. [Conclusion] Heparin promoted pulmonary vascular proliferation probably due to increased expression of VEGF. Selective intermittent administration of VEGF is possibly a less invasive treatment to promote pulmonary vascular maturation.
[目的]阐明肝素在肺血管增殖中的作用,探索促进肺血管成熟的治疗方法。[方法与结果]新生兔皮下注射肝素(肝素组)、鱼精蛋白(鱼精蛋白组)或生理盐水(对照组),共14天。用计算机分析系统测得的肺毛细血管密度,肝素组最高,对照组次之,鱼精蛋白组最低。免疫组织化学染色显示血管内皮细胞生长因子含量最高,依次为肝素组、对照组、鱼精蛋白组。右室压以肝素组最低,生理盐水组居中,鱼精蛋白组最高。[结论]肝素促进肺血管增殖可能是通过增加血管内皮生长因子的表达来实现的。选择性间歇应用血管内皮生长因子可能是一种促进肺血管成熟的微创治疗方法。

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
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ENDO Masato其他文献

ENDO Masato的其他文献

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{{ truncateString('ENDO Masato', 18)}}的其他基金

Live food production using waste materials discharged from marine fish culture system
利用海水鱼类养殖系统排出的废物生产活食品
  • 批准号:
    20780135
  • 财政年份:
    2008
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Accelerated maturation of pulmonary vasculature by VEGF selective delivery system
通过 VEGF 选择性递送系统加速肺血管系统的成熟
  • 批准号:
    14370399
  • 财政年份:
    2002
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Research for protection of pulmonary function during cardiopulmonary bypass
体外循环期间肺功能保护研究
  • 批准号:
    12671291
  • 财政年份:
    2000
  • 资助金额:
    $ 1.6万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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