Investigation of the method of the treatment for tracheal stenosis using prosthetic trachea and/or transplantation of tracheal homograft

点击翻译按钮获取中文摘要

(Study 1) Materials and Methods : We studied the period that rejection were weakest in tracheal graft of rabbits, which was influenced by MHC Class □ antigen, and that the epithelium of tracheal graft might be able to regenerate.RESULTS : We found that MHC class □ antigen was decreased over 8 weeks after tracheal graft was preserved in cryogen and MHC class □ antigen was disappeared 20 weeks after that. In two of three cases, the epithelium oftracheal graft were not recovered 16 weeks after that. CONCLUSION : 8 weeks to 12 weeks were best periods to preserve tracheal graft in cryogen. Further study was needed to clarify this findings.(Study 2) Materials and Methods : The cytologic findings of the tumor cells corresponding to the stages in thymomas were investigated to assess their infiltrating nature.RESULTS : Compared with cytologic findings of stage I or II thymomas, those of epithelial tumor cells in stage III or IV more frequently revealed necrotic background (50.0 %-stage III or IV vs 11.1 %- stage I or II, p=0.006), large cluster of epithelial tumor cells (70.0 % vs 36.1 %, p=0.055), marked nuclear enlargement (90.0 % vs 52.7 %, p=0.033), marked anisokaryosis (100 % vs 52.7 %, p=0.006), marked nuclear polymorphism (40.0 % vs 5.5 %, p=0.004), hyperchromasia (50.0 % vs 11.4 %, p=0.007) and prominent nucleoli (50.0 % vs 16.6 %, p=0.028)CONCLUSION : Our findings revealed that there was a significant difference in the cytologic findings of epithelial tumor cells between stage I or II thymomas and stage III or IV those, and the cytologic findings of thymoma tumor cells appears to capacitate to distinguish between non invasive and invasive thymomas.(Study 3) OBJECTIVE : We studied the utility of Endobronchial ultrasonography (EBUS) to observe the bronchial cartilage.Conclusion : EBUS was very useful to observe the tracheal cartilage and we were able to examine the tracheal wall.