The effects of anesthetics on skin incision induced WDR neuronal activity in cat
The effects of anesthetics on skin incision induced WDR neuronal activity in cat
批准号:
10671442
负责人:
NAGASAKA Hiroshi
金额:
$0.64万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
1998
资助国家:
日本
项目状态:
已结题
起止时间:
1998 至 1999
中文摘要
Adult cats of both sexes were used in all experiments。The experimental protocol was approved by our Institutional Animal Care and Use Committee and the ethical guidelines for the treatment of animals of the International Association for the Study of Pain were followed.All surgical procedures were performed under halothane-nitrous oxide-oxygen anesthesia.We investigated the effects of ketamine on the activity of WDR neurons in the spinal dorsal horn that was evoked by skin incision in cats.In addition,we studied the effects of pre-and post-administration of ketamine on the maintained phase of the skin incision response。Each dose was a subanesthetic or anesthetic.(3.0毫克千克D1-1千克D1,10毫克千克D1-1)。Intravenous administered ketamine produced a dose dependent depression of evoked activity that was not significantly greater when drug was administered before skin incision.However,we can‘t observe a benefit of a clear preemptive effect of ketamine in cat。
英文摘要
Adult cats of both sexes were used in all experiments. The experimental protocol was approved by our Institutional Animal Care and Use Committee and the ethical guidelines for the treatment of animals of the International Association for the Study of Pain were followed. All surgical procedures were performed under halothane - nitrous oxide -oxygen anesthesia. We investigated the effects of ketamine on the activity of WDR neurons in the spinal dorsal horn that was evoked by skin incision in cats. In addition, we studied the effects of pre- and post-administration of ketamine on the maintained phase of the skin incision response. Each dose was a subanesthetic or anesthetic. (3.0 mg kgィイD1-1ィエD1, 10 mg kgィイD1-1ィエD1). Intravenous administered ketamine produced a dose dependent depression of evoked activity that was not significantly greater when drug was administered before skin incision. However, we can't observe a benefit of a clear preemptive effect of ketamine in cat.
期刊论文(5)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Nagasaka H et al: "Effect of ketamine on formalin-induced activity in the spinal dosal horn of spinal cord-transected cat"Acta Anaesth. Scand. (in press). (2000)
Nagasaka H 等人:“氯胺酮对脊髓横断猫脊髓背角福尔马林诱导活动的影响”Acta Anaesth。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
DL DeHaven-Hudkin: "ADL2-1294,an opioid antihyperlgesic agent with peripheral selectivity" J Pharmacol Exp ther. (1999)
DL DeHaven-Hudkin:“ADL2-1294,一种具有外周选择性的阿片类抗过敏药”J Pharmacol Exp ther。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
H.Nagasaka: "Effects of ketamine on formalin induced activity in the spinal dorsal horn of spinal cord-transeited cats."Ata Anaesth Scand. (in press). (2000)
H.Nagasaka:“氯胺酮对福尔马林诱导的脊髓转运猫脊髓背角活动的影响。”Ata Anaesth Scand。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
初雁育介、長坂浩他: "AVMを合併した妊婦の麻酔経験"麻酔. 49. 33-36 (2000)
Ikusuke Hatsugan、Hiroshi Nagasaka 等:“AVM 孕妇的麻醉经验” 麻醉 49. 33-36 (2000)。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
初雁育介、長坂 浩その他: "脳動静脈奇形(AVM)を合併した妊婦の麻酔経験"麻酔. 49. 33-36 (2000)
Ikusuke Hatsugan、Hiroshi Nagasaka等:“脑动静脉畸形(AVM)孕妇的麻醉经验”麻醉49. 33-36(2000)。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Autophagy-inducing activity of anesthetics against various malignant cells
-
批准号:21591987
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.33万
-
财政年份:2009
-
负责人:NAGASAKA Hiroshi
-
依托单位:
Induction of apoptosis by anesthetics I n the human cancer cell lines
-
批准号:16591560
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
-
财政年份:2004
-
负责人:NAGASAKA Hiroshi
-
依托单位:
Induction of apoptosis by anesthetics in the human cancer cell lines.
-
批准号:13671609
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.28万
-
财政年份:2001
-
负责人:NAGASAKA Hiroshi
-
依托单位:
Experimental Study On Orthodontic Tooth Movement Through Alveolar Bone Regenerates Following Mandibular Distraction Osteogenesis in Dogs
-
批准号:11672035
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.24万
-
财政年份:1999
-
负责人:NAGASAKA Hiroshi
-
依托单位:
海外基金