The effects of anesthetics on skin incision induced WDR neuronal activity in cat

两只性感的成年猫都在所有的实验中使用过。该实验协议是由我们的机构动物护理和使用委员会批准的，以及国际动物协会对疼痛研究的治疗的道德指导方针。所有外科手术都是performed under halothane-nitrous oxide-oxygen anesthesia。我们研究了氯胺酮对WDR神经元活动在脊柱角上的影响，这是由猫的皮肤不适引起的。在补充中，我们研究了氯胺酮前和后管理对皮肤过敏反应阶段的影响。每一种剂量都是无意义的或无意义的。（3.0 mg kg伊D1-1伊D1， 10 mg kg伊D1-1伊D1）。受影响的管理员产生了受影响的活动的剂量依赖性抑郁症，但在药物被管理前并不明显。However，我们不能观察到一个明显的、预先作用的好处在猫中。

Adult cats of both sexes were used in all experiments. The experimental protocol was approved by our Institutional Animal Care and Use Committee and the ethical guidelines for the treatment of animals of the International Association for the Study of Pain were followed. All surgical procedures were performed under halothane - nitrous oxide -oxygen anesthesia. We investigated the effects of ketamine on the activity of WDR neurons in the spinal dorsal horn that was evoked by skin incision in cats. In addition, we studied the effects of pre- and post-administration of ketamine on the maintained phase of the skin incision response. Each dose was a subanesthetic or anesthetic. (3.0 mg kgィイD1-1ィエD1, 10 mg kgィイD1-1ィエD1). Intravenous administered ketamine produced a dose dependent depression of evoked activity that was not significantly greater when drug was administered before skin incision. However, we can't observe a benefit of a clear preemptive effect of ketamine in cat.