Effect of heavy charged particles on the normal eye

目标：重电荷的碳颗粒是一种辐射，并且开始被用作对恶性肿瘤的某些类型的治疗。哇，这种治疗从来没有被应用在眼睛上。对轨道恶性肿瘤的辐射的一项试验研究刚刚在日本开始。自从有少数报告提供了关于其对视网膜的影响，我们研究了对视网膜和克里斯汀镜头的重电荷颗粒辐射的影响。方法：湿鼠（8周老，重量约150克）是在本研究中使用的。右眼睛暴露在5种不同单一剂量（1、2、4、8和16戈瑞）下的重型碳（D112、D1C）粒子辐射中，一般对氯胺酮、氯胺酮和苯丙胺的过敏。六种没有辐射的动物被用作控制。水晶球透镜的不稳定性用外科显微镜和闪光ERG记录在辐射后1、3和6个月内评估视网膜功能。结果：1个月 ... More 在辐射大鼠被辐射为8和16戈瑞显示出明显高的目录效应后，在3个月内所有老鼠辐射为16戈瑞显示出成熟目录。在1 - 3个月内，在任何剂量的A-wave的振幅中没有明显的变化，但在老鼠辐射的16 Gy中没有明显的B波振幅衰减的振幅。辐射后6个月，老鼠辐射后8和16戈瑞显示了b波的振幅有统计意义的衰减，但振幅或a波仍然正常。在老鼠身上，没有明显的变化。结论：在辐射后，8戈瑞和16戈瑞的单一辐射导致了直接辐射。视网膜未被重电荷粒子的低剂量（1、2和4戈瑞）所损坏。但剂量很高（8和16戈瑞）导致长期功能损伤，可能在短期内没有影响。Our results Could provide important information to Apply the Eye D112 Eye D1C particles irradiation on the Eye Clinically. Less（低）

Objectives : Heavy charged carbon particles are one kind of radiation and have begun to be used as the treatment for certain kinds of malignant tumors. However, this treatment has never been applied on the eye. A trial study of its irradiation on the orbital malignant tumors has just started in Japan. Since few reports are available about its influence on the retina, we studied the influence of heavy charged particles irradiation on the retina and crystalline lens.Methods : Wister rats (8 week-old, weighting about 150g) were used in this study . Right eyes were exposed to heavy charged carbon (ィイD112ィエD1C) particles irradiation in 5 different single doses (1, 2, 4, 8 and 16Gy) under general anesthesia with ketamine, xylazine and urethane. Six animals without irradiation were used as controls. The opacity of crystalline lens were evaluated with a surgical microscope and flash ERGs were recorded to evaluate retinal function at 1, 3 and 6 months after the irradiation.Results : At 1 month … More after the irradiation rats irradiated 8 and 16Gy showed significantly high incidence of cataract, and at 3 months all mice irradiated 16 Gy showed mature cataract. At 1 and 3 months, there were no significant changes in the amplitude of the a-waves in ERGs in any dose, but the amplitude of b-wave decreased significantly in the rats irradiated 16 Gy. At 6 months after the irradiation, the rats irradiated 8 and 16 Gy showed statistically significant decrease of the amplitudes of b-waves, but the amplitude od a-wave remained normal. In the rats with lower doses, there were no significant changes.Conclusions : With single irradiation of 8 Gy and 16 Gy cause cataract shortly after the irradiation. The retinae were not damaged with low doses (1, 2, and 4Gy) of heavy charged particles. But high dose (8 and 16Gy) caused retinal functional damage in a long term, although it has no influence in a short term. Our results could provide important information to apply the ィイD112ィエD1C particles irradiation on the eye clinically. Less