Study of the simulation model of blood flow insufficiency in the human eyes.

已知眼血流量与眼灌注压、血黏度和血管直径有显著关系。另一方面，为了在这些参数发生变化的情况下维持血液的持续流动，眼内存在神经自调节机制。本研究旨在探讨正常人眼眼血流动力学与神经自动调节机制之间的关系。在卡替洛尔（β -肾上腺素能拮抗剂）治疗的眼睛中，与安慰剂治疗的眼睛相比，眼动脉的血流量速度和乳头周围视网膜的血流量显着增加。两眼眼内压和眼灌注压较对照组明显降低。这些结果表明，局部β -肾上腺素能拮抗剂增加眶内微循环和乳头周围视网膜的血流量。近红外低空激光照射星状神经节附近区域，被照射侧眼睛视神经头血流量较对照研究明显增加。眼压、眼灌注压、全身血压、瞳孔直径无明显变化。这些结果表明，近红外低水平激光照射星状神经节附近区域增加了视神经头的血流量，但没有改变其他神经参数。这些研究表明，眼血流受眼内和眼外区域存在的神经自调节机制的调节。

It is known that ocular blood flow has significantly related to ocular perfusion pressure, blood viscosity and blood vessel diameter. On the other hand, in order to maintain the blood flow constantly spite of the changes of these parameters, there is neural auto-regulated mechanism in the eye. The purpose of this study is to investigate the relationship between the ocular blood flow dynamics and neural auto-regulated mechanism in the normal human eyes.In the carteolol (beta-adrenergic antagonist) treated eyes, the blood flow velocrty of the ophthalmic artery, and blood flow volume of the peripapillary retina showed significant increases, compared with the placebo-treated eyes. Intraocular pressure and ocular perfusion pressure showed significant reduction compared with control study both or eyes. These results indicated that the topical beta-adrenergic antagonist increases the blood flow of the intraorbital microcirculation and peripapillary retina.In the near-infrared low-level laser irradiation on the area near the stellate ganglion, the eyes on the irradiated side, blood flow volume of the optic nerve head showed significant increases compared with the control study. However, intraocular pressure, ocular perfusion pressure, systemic blood pressure and pupil diameter showed no significant changes. These results suggest that the near-infrared low-level laser irradiation on the area near the stellate ganglion increases the blood flow of the optic nerve head without the changes of other neural parameters.These studied demonstrated that ocular blood flow is regulated by the neural auto-regulated mechanism existed in the intraocular and extraocular regions.