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Study of the simulation model of blood flow insufficiency in the human eyes.

人眼血流不足的模拟模型研究。

基本信息

批准号：
10671660
负责人：
YAMAZAKI Yoshio
金额：
$ 1.41万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

It is known that ocular blood flow has significantly related to ocular perfusion pressure, blood viscosity and blood vessel diameter. On the other hand, in order to maintain the blood flow constantly spite of the changes of these parameters, there is neural auto-regulated mechanism in the eye. The purpose of this study is to investigate the relationship between the ocular blood flow dynamics and neural auto-regulated mechanism in the normal human eyes.In the carteolol (beta-adrenergic antagonist) treated eyes, the blood flow velocrty of the ophthalmic artery, and blood flow volume of the peripapillary retina showed significant increases, compared with the placebo-treated eyes. Intraocular pressure and ocular perfusion pressure showed significant reduction compared with control study both or eyes. These results indicated that the topical beta-adrenergic antagonist increases the blood flow of the intraorbital microcirculation and peripapillary retina.In the near-infrared low-level laser irradiation on the area near the stellate ganglion, the eyes on the irradiated side, blood flow volume of the optic nerve head showed significant increases compared with the control study. However, intraocular pressure, ocular perfusion pressure, systemic blood pressure and pupil diameter showed no significant changes. These results suggest that the near-infrared low-level laser irradiation on the area near the stellate ganglion increases the blood flow of the optic nerve head without the changes of other neural parameters.These studied demonstrated that ocular blood flow is regulated by the neural auto-regulated mechanism existed in the intraocular and extraocular regions.

众所周知，眼部血流量与眼部灌注压、血液粘度和血管内径有显著的相关性。另一方面，为了在这些参数发生变化的情况下保持不变的血流，眼睛中存在着神经自动调节机制。本研究旨在探讨正常人眼血流动力学与神经自动调节机制之间的关系。与安慰剂组相比，卡替洛尔(β-肾上腺素能拮抗剂)治疗眼的眼动脉血流速度和视乳头周围视网膜血流量显著增加。双眼或双眼的眼压和眼血流灌注压均较对照研究组显著降低。这些结果表明，外用β-肾上腺素能拮抗剂增加了眶内微循环和视乳头周围视网膜的血流量。在近红外低强度激光照射星状神经节附近区域时，受照侧眼睛的视神经头血流量比对照研究明显增加。而眼压、眼灌注压、全身血压和瞳孔直径无明显变化。这些结果表明，近红外低强度激光照射星状神经节附近区域，增加了视神经头的血流量，而其他神经参数没有变化。这些研究表明，眼血流是由眼内外存在的神经自动调节机制调节的。