The pathogenesis and simulation model of autonomic nerve response in the intraocular blood flow disorders

眼内血流障碍自主神经反应的发病机制及模拟模型

• 批准号: 14571690
• 负责人: YAMAZAKI Yoshio
• 金额: $ 1.73万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571690/
• 关键词: retrobulbar blood microcirculation; ocular hypertension; blood vessel dilation; autonomic nerve; reduction of intraocular pressure; ocular perfusion pressure; 網膜神経細胞; 眼循環; 交感神経; 炭素脱水酵素; コンピュータ・シミュリレーション

[Background/aim] The intraocular blood flow is autoregulated over wide range of ocular perfusion pressure (OPP). The purpose of this study is to investigate whether a reduction of intraocular pressure (IOP) may improve intraocular hemodynamics in human eyes.[Methods] 26 patients with primary open angle glaucoma (POAG) about to undergo trabeculectomy were included in the study. Patients were evaluated before surgery and at 3,6,9,12 months after trabeculectomy. Blood flow resistance of central retinal artery (CRA) and short posterior ciliary artery (SPCA) in both eyes were assessed with color Doppler imaging. Function of retinal ganglion cells were obtained with visual field examination.[Results] IOP in the operated eye was significantly decreased after trabeculectomy, and OPP was significantly increased for each postoperative visits. Blood flow resistance of CRA and SPCA were significantly decreased, and retinal light sensitivity was significantly increased in the operated eye. IOP in the unoperated eye, OPP, blood flow resistance of CRA and SPCA, and retinal light sensitivity did not significantly change.[Conclusion] The results of this study suggest that a reduction of IOP improves ocular blood flow and function of retinal ganglion cell in patients with POAG.

[背景/目的] 眼内血流在较宽的眼灌注压（OPP）范围内进行自动调节。本研究的目的是探讨降低眼压（IOP）是否可以改善人眼的眼内血流动力学。[方法]本研究纳入26例即将接受小梁切除术的原发性开角型青光眼（POAG）患者。在手术前和小梁切除术后3、6、9、12个月对患者进行评估。通过彩色多普勒成像评估双眼视网膜中央动脉（CRA）和睫状后短动脉（SPCA）的血流阻力。通过视野检查了解视网膜神经节细胞的功能。[结果]小梁切除术后眼压明显下降，术后每次复诊眼压明显升高。手术眼CRA和SPCA的血流阻力显着降低，视网膜光敏感度显着增加。未手术眼的眼压、OPP、CRA和SPCA的血流阻力以及视网膜光敏感度没有明显变化。[结论]本研究结果提示，降低眼压可以改善POAG患者的眼部血流和视网膜神经节细胞功能。

项目成果

Influence of optic disc appearance and diurnal variation of intraocular pressure on visual field defect in normal tension glaucoma

视盘外观及眼压日变化对正常眼压性青光眼视野缺损的影响

• 发表时间: 2004
• 期刊: Perimetry Update 2002/2003
• 作者: Yoshio Yamazaki;Takako Nakagami;Taiki Oshida;Kenji Mizuki;Fukuko Hayamizu;Chizuru Tanaka
• 通讯作者: Chizuru Tanaka

Influence of optic disc appearance and diurnal variation of intraocular pressure on visual field defect in normal tension glaucoma.

视盘外观和眼压日变化对正常眼压青光眼视野缺损的影响。

• 发表时间: 2004
• 期刊: Perimetry Update 2002/2003
• 作者: Yoshio Yamazaki

山崎芳夫, 他: "原発開放隅角緑内障に対する非穿孔性線維柱帯切除術の術後成績の検討"日本眼科学会雑誌. 108・2. 103-109 (2004)

Yoshio Yamazaki等：“原发性开角型青光眼的非穿透性小梁切除术术后结果的研究”日本眼科学会杂志108・2（2004年）。

Prognostic factors for progression of visual field damage in patient with normal tension glaucoma

正常眼压性青光眼患者视野损伤进展的预后因素

• 发表时间: 2005
• 期刊: Japanese Journal of Ophthalmology (in press)
• 作者: Takako Nakagami;Yoshio Yamazaki;Fukuko Hayamizu
• 通讯作者: Fukuko Hayamizu

Effect of ocular hypotensive medications in preventing the progression of visual field damage in patients with normal tension glaucoma

降眼压药物预防正常眼压性青光眼患者视野损伤进展的效果

• 发表时间: 2004
• 期刊: Nippon Gannka Gakkai Zasshi 108
• 作者: Takako Nakagami;Yoshio Yamazaki;Fukuko Hayamizu;Chizuru Tanaka
• 通讯作者: Chizuru Tanaka