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Reconstruction of a three-dimensional structure using cartilage regenerated from the perichondrium.

使用软骨膜再生的软骨重建三维结构。

基本信息

批准号：
10671677
负责人：
YOTSUYANAGI Takatoshi
金额：
$ 2.05万
依托单位：
Hirosaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

In auricular deformities, nonsurgical treatment using splints or surgical tapes has been said to be not effective except in early neonates. We studied nonsurgical correction in 50 children older than early neonates. Namely, they were 26 cryptotias, 5 lop ears, 5 Stahl's ears, 3 prominent ears, 3 shell ears, and 8 other miscellaneous conditions. We used thermoplastic materials as a splint and succeeded in correcting or improving the deformities in 38 patients. As a results of this study, we suggested that nonsurgical auricular correction is suitable in almost all children, even if they were not early neonates, when corrections were made continuously and gradually.We devised a new reconstructive technique for lost tissues by using cartilage regenerated from the perichondrium. The layer between the perichondrium and the cartilage was stripped off. The exposed cartilage was punched out in large amounts to resemble a flexible, honeycomb-like structure. Then we sandwiched the rabbit ears between two thermoplastic plates, which maintained the structure of the anterior surface of the human ear for 8 weeks. Structural change was studied in all of these animal cases, and some parts of the remodeled tissue were studied pathologically. Out of 12 ears, 8 had a rigid structure with a shape like a human ear using regenerated cartilage from the perichondium of rabbits. This study suggested that the use of cartilage regenerated from the perichondrium might lead to a successful treatment also in humans for a variety of three-dimensional structures that have been damaged. We also tried a use of rh-BMPin the trial and had a result that a cartilage regeneration can not be effected by this drug but bone regeneration becomes a new other technique for reconstruction of a three-dimensional structure.

在耳部畸形中，使用夹板或手术胶带的非手术治疗据说除了在早期新生儿中之外是无效的。我们研究了50例年龄大于早期新生儿的非手术矫正。其中隐耳26只，垂耳5只，斯塔尔耳5只，突耳3只，壳耳3只，其它8只。我们用热塑材料作夹板，成功地矫正或改善了38例畸形。作为这项研究的结果，我们认为，非手术耳廓矫正是适合于几乎所有的儿童，即使他们不是早期的新生儿，当纠正是连续和渐进的。我们设计了一种新的重建技术，失去的组织使用软骨膜再生软骨。软骨膜和软骨之间的层被剥离。暴露的软骨被大量冲压出来，看起来像一个灵活的蜂窝状结构。然后，我们将兔耳夹在两个热塑性板之间，保持人耳前表面的结构8周。在所有这些动物病例中研究了结构变化，并对重塑组织的某些部分进行了病理学研究。在12只耳中，8只具有刚性结构，其形状类似于使用来自兔软骨膜的再生软骨的人耳。这项研究表明，使用从软骨膜再生的软骨可能会导致成功的治疗，也在人类的各种三维结构已被损坏。我们还在试验中尝试使用rh-BMP，结果是软骨再生不能受该药物的影响，但骨再生成为重建三维结构的另一种新技术。