Analysis of newborn airway aspirate and colostrum collected by midwives : Judging the mother-child health status and influences on nursing care.

助产士采集的新生儿气道吸出液和初乳分析：判断母婴健康状况及对护理的影响。

• 批准号: 10672242
• 负责人: TERAO Toshiko
• 金额: $ 2.24万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10672242/
• 关键词: newborn airway aspirate; preterm infants; SP-A; respiratory distress syndrome; BLF; BALF; human airway trypsin-like protease; S-IgA; 肺サーファクタント; 低出生体重児; s-IgA; 新生児; 気道吸引液; 肺表面活性物質; 生化学的分析

1 The NAA SP-A level and the ratio of the SP-A level to the total protein level in NAA (the TP ratio) both tended to be lower among neonates born after shorter gestational ages, and they were particularly low among neonates with respiratory distress syndrome (RDS). NAA contains human airway trypsin-like protease (HAT), which is thought to be involved in the physiological functions of the airway, we biochemically analyzed trypin-like enzymes contained in NAA.2 We measured contents of tracheobronchial and alveolar components contained in the newborn airway aspirates (NAA) obtained from 30 normal newborns, with bronchoalveolar lavage fluid (BALF) and bronchial lavage fluid (BLF) from healthy adults as controls. NAA may be useful for diagnosing pathologic conditions in the airway of the newborns, and for comparing the biological defense mechanism between newborns and adults.3 To examined NAA's relationship to maternal factors during pregnancy and in the peri-labor period, and neonatal factors. None of the neonatal factors ana differed significantly between the two groups.4 NAA are useful samples for clinical diagnosis of newborn respiratory disorders, the pulmonary surfactant (PS) content in NAAs from 19 term infants without respiratory problems (Group I) was compared with those from 14 preterm infants (Group II) and 3 infants with respiratory distress syndrome (RDS, Group III).

1.短胎龄新生儿的NAA SP-A水平和NAA中SP-A水平与总蛋白水平的比值（TP比值）均呈下降趋势，尤其是呼吸窘迫综合征（RDS）新生儿。NAA中含有人气道胰蛋白酶样蛋白酶（HAT），它被认为参与气道的生理功能，我们对NAA中所含的胰蛋白酶样酶进行了生化分析。2测定了30例正常新生儿的新生儿气道吸出物（NAA）中气管、支气管和肺泡成分的含量，以健康成人支气管肺泡灌洗液（BALF）和支气管灌洗液（BLF）为对照。NAA可用于诊断新生儿气道的病理状态，并可用于比较新生儿与成人气道的生物防御机制。3探讨NAA与母孕期、围产期因素及新生儿因素的关系。本文对19例无呼吸系统疾病足月儿（I组）、14例早产儿（II组）和3例呼吸窘迫综合征（RDS，III组）NAAs中肺表面活性物质（PS）含量进行了比较。

项目成果

Toshiko Terao.: "Analysis of the pulmonary surfactant-associated protein, SP-A in newborn airway aspirates from term and preterm infants"J.jpn.Med.Soc.Biol.Interface. 31. 41-48 (2000)

Toshiko Terao.：“足月儿和早产儿新生儿气道抽吸物中肺表面活性物质相关蛋白 SP-A 的分析”J.jpn.Med.Soc.Biol.Interface。

Toshiko Terao.: "Diagnostic value of newborn airway aspirate : Analysis of active substances on the lung's surface and of proteases."Department of Mathematical and Natural Sciences, Faculty of Arts and Sciences, The University of Tokushima, (Treatise Mast

Toshiko Terao.：“新生儿气道抽吸物的诊断价值：肺表面活性物质和蛋白酶的分析。”德岛大学艺术与科学学院数学和自然科学系，（论文桅杆）

寺尾紀子: "正常新生児と早産児の新生児気道吸引液の肺サーファクタントアポタンパク、SP-Aの分析"J.Jpn.Med.Soc.Biol.Interface. 31. 41-48 (2000)

Noriko Terao：“正常新生儿和早产儿新生儿气道抽吸物中肺表面活性物质脱辅基蛋白和 SP-A 的分析”J.Jpn.Med.Soc.Biol.Interface 31. 41-48 (2000)。

寺尾紀子: "新生児気道吸引液の成分分析とその関連要因の検討"徳島大学医療技術短期大学部看護学科集録.

寺尾纪子：《新生儿气道抽吸液成分分析及相关因素研究》德岛大学医学技术学院护理学系论文集。

Toshiko Terao,Eriko Harada,Sumiko Yoshinaga,Fumiko Michishige,Akiko Kitamura,Susumu Yasuoka: "Analysis of pulmonary surfactant-associated protein,SP-A in newborn airway aspirates from healthy and low birth weight infants"第35回界面医学会誌. 28-29 (1999)

Toshiko Terao、Eriko Harada、Sumiko Yoshinaga、Fumiko Michishige、Akiko Kitamura、Susumu Yasuoka：“健康和低出生体重婴儿新生儿气道抽吸物中肺表面活性物质相关蛋白 SP-A 的分析”第 35 期界面医学杂志 28 -。 29 (1999)