Study on the Distribution Behavior and Toxicity of Metallic Wear Particles and Ion Released from Total Knee Prosthesis.

点击翻译按钮获取中文摘要

We surgically obtained two Co-Cr-Mo and five Ti-Al-V alloy knee prosthesis which were retrieved due to mechanical failure and pain. We examined the distribution and the size of the small particles which were released from Co-Cr-Mo and Ti-Al-V alloy using backscattered SEM and TEM. In addition we analyzed the metal ions in the adjacent tissues of the knee prosthesis by energy dispersive X-ray spectroscopy(EDS).We observed that small particles were detected evenly in the synovial tissues and the particles contained Co-Cr-Mo and Ti-Al-V alloy components. Metallic wear particles were phagocyted by the cells next to the synovial bursae and showed bulky or needle-like structures. We demonstrated that both Co-Cr-Mo particles and Cr particles were present in the cells adjacent to Co-Cr-Mo alloy, although Ti-Al-V particles alone were found in cases using Ti-Al-V alloy prosthesis. These results suggest that Co ion released from Co-Cr-Mo alloy enters the surrounding tissues as well as blood stream and damages the body.