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Research about rehabilitation of motor disability by using the magnetic stimulation

磁刺激康复运动障碍的研究

基本信息

批准号：
10838002
负责人：
CHUMA Takayo
金额：
$ 2.05万
依托单位：
HOKKAIDO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10838002/
关键词：
repetitive transcranial magnetic stimulation learning and memory Morris's water maze test repetitive magnetic stimulation biceps brachii muscle contraction time half relaxation time post-tetanic potentiation 連続磁気刺激 Morris水迷路試験

项目摘要

The rTMS (repetitive transcranial magnetic stimulation) was reported the effect for depression state. In 1998, we studied the safety and the clinical usefulness of rTMS using normal mice. We divided three groups and stimulated the mice by rTMS (group I : rTMS at 10Hz for 10sec, group II : rTMS at 3Hz for 60sec, group III : non-rTMS) using the intensity of two types : 130% and 90% of motor threshold. After rTMS, we evaluated about the learning and the memory of the mice received rTMS, using Morris's water maze test. The mice of group I and group II seemed to be lower in the learning and the memory, but the effects of rTMS was transient. We thought that the rTMS was safe in above intensity, frequency, train of magnetic stimulation and the interval of each train of magnetic stimulation.In 1999, we tried to study the contraction patterns of human biceps brachii muscle using magnetic stimulation. We measured contraction time and relaxation time of the contraction patterns. The contraction time between male and female was no different but the half relaxation time of female was longer than that of male, This difference was thought that ratio of fast twitch unit and slow twitch unit might be different between male and female. Next, we examined tetanic contraction by repetitive magnetic stimulation of 50Hz for 0.5sec. The twitch tension of single twitch after train of repetitive magnetic stimulation was larger than the twitch tension before the train. This was thought to be post-tetanic potentiation. Repetitive magnetic stimulation to human was a useful and simple method to analyze the pattern muscular contraction of human proximal muscles and might be clinically applicable.

据报道，rTMS（重复经颅磁刺激）对抑郁状态有影响。 1998年，我们用正常小鼠研究了rTMS的安全性和临床实用性。我们将小鼠分为三组，并使用两种类型的强度：运动阈值的 130% 和 90%，通过 rTMS 刺激小鼠（第一组：rTMS 在 10Hz 下持续 10 秒，第二组：rTMS 在 3Hz 下持续 60 秒，第三组：非 rTMS）。在rTMS之后，我们使用莫里斯的水迷宫测试评估了接受rTMS的小鼠的学习和记忆能力。 I组和II组的小鼠学习记忆能力似乎较差，但rTMS的效果是短暂的。我们认为rTMS在上述强度、频率、磁刺激序列以及每列磁刺激的间隔时间上是安全的。1999年，我们尝试利用磁刺激研究人体肱二头肌的收缩模式。我们测量了收缩模式的收缩时间和松弛时间。男性和女性的收缩时间没有差异，但女性的半弛豫时间比男性长，这种差异被认为可能是男性和女性之间快肌单位和慢肌单位的比例不同。接下来，我们通过 50Hz 重复磁刺激 0.5 秒来检查强直性收缩。重复磁刺激训练后的单次抽搐的抽搐张力大于训练前的抽搐张力。这被认为是强直后增强。对人体进行重复磁刺激是分析人体近端肌肉肌肉收缩模式的一种有用且简单的方法，并且可能在临床上适用。