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The clinical research of repetitive transcranial magnetic stimulation for patients with central nervous disorders

重复经颅磁刺激治疗中枢神经障碍的临床研究

基本信息

批准号：
18300180
负责人：
CHUMA Takayo
金额：
$ 6.71万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18300180/
关键词：
repetitive transcranial magnetic stimulation Parkinson's disease dorsolateral prefrontal cortex motor function modified Stroop test frontal lobe function 第一次運動野

项目摘要

rTMS (repetitive transcranial magnetic stimulation) has been reported for central nervous disorders. In 2006, we studied the effect of rTMS using 11 patients with Parkinson's disease. The patients received high frequency rTMS (10Hz, 1000pulses, intensity; 80% motor threshold) over left primary motor cortex, right motor cortex, left dorsolateral prefrontal cortex (DLPFC), right DLPFC, compared to sham stimulation. We measured time of modified Stroop test, 10m walking time and grasping power before rTMS and after rTMS. The time of modified Stroop test after rTMS over DLPFC became shorter than that before rTMS. This suggests that rTMS over DLPFC induced the effect on the frontal lobe function in patients with Parkinson's disease.In 2007, we studied the effect of rTMS for a long time. The subjects were three patients with Parkinson's disease. The patients received high frequency rTMS (5Hz, 1000pulses, intensity; 80%motor threshold) over bilateral DLPFC. We measured modified Stroop test, 10m walking time and grasping power before rTMS and after 8-9 months of rTMS course. The grasping power after rTMS course became larger than that before rTMS. The time of modified Stroop test was not improved after rTMS course. Then, this suggests that regular rTMS might improve motor function of patients with Parkinson's disease without complications.

据报道，rTMS（重复经颅磁刺激）可用于治疗中枢神经系统疾病。2006年，我们研究了11例帕金森病患者的rTMS效果。在左侧初级运动皮层、右侧运动皮层、左侧背外侧前额叶皮层（DLPFC）、右侧DLPFC接受高频rTMS（10Hz，1000个脉冲，强度; 80%运动阈值）刺激，并与假刺激进行比较。分别测量rTMS前后改良Stroop试验时间、10 m步行时间和抓握力。改良Stroop试验时间在DLPFC上rTMS后较rTMS前缩短。这表明rTMS比DLPFC对帕金森病患者的额叶功能产生了影响。受试者是三名帕金森病患者。患者在双侧DLPFC接受高频rTMS（5Hz，1000个脉冲，强度; 80%运动阈值）。分别于治疗前和治疗后8-9个月测量改良Stroop测验、10 m步行时间和抓握力。经颅磁刺激治疗后抓握力较治疗前增强。改良Stroop测验时间在rTMS治疗后无明显改善。因此，这表明定期rTMS可能会改善帕金森病患者的运动功能，而不会出现并发症。