Relations between the renal hypertension which minded renin-angiotensin system and the renal failure

介导肾素-血管紧张素系统的肾性高血压与肾功能衰竭的关系

• 批准号: 10839018
• 负责人: WATANABE Toshifumi
• 金额: $ 1.86万
• 依托单位: AZABU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10839018/
• 关键词: HYPERTENSION; RENAL HYPERTENSION; RENIN-ANGIOTENSIN; CHRONIC RENAL FAILURE; TEREMETRY; ACE-INHIBITOR

The cases of chronic renal failure have recently grown in small animal clinics like human patients. The methodological studies of diagnosis and therapy have been thus conducted but no detailed description of renal hypertension has been presented. Therefore, we report herein the possible contribution of renal disorders to the pathogenesis of renal hypertension in cat models of chronic renal failure using a telemetry system that allows monitoring the blood pressure in awake unrestrained animals for 24 consecutive hours, focusing on the blood pressure and certain parameters in the renin-angiotensin-alsosterone system. Moreover, we will describe the effect of an angiotensin converting enzyme inhibitor on renal hypertension in the present animal models of chronic renal failure. [Results] The evaluation of renal function in the 5 cats demonstrated significantly elevated BUN and serum Cr levels (p<0.05) and lowered CCr (p<0.05) after the operation for chronic renal failure when compared with … More the preoperative values. In addition, the systolic, mean and diastolic pressures after the operation were all significantly higher than the control values (p<0.05). Plasma renin activity, angiotensin I (ANG-I), angiotensin II (ANG-II) and ALD were all significantly elevated after the operation when compared with the preoperative values (p<0.05). In the animal models of chronic renal failure, benazepryl hydrochloride produced a significant fall in systolic, mean and diastolic pressures during the treatment period when compared with the pre-treatment levels (p<0.05). The pressures returned to almost the same as the pre-treatment levels after the discontinuation of the drug. At the same time, the ACE-I led to the significant decreases in plasma angiotensin II and ALD during the treatment period (p<0.05), followed by the sustained low levels after the discontinuation of the drug. On the other hand, the ACE-I did not alter either plasma renin activity or angiotensin I (ANG-I) level during the observation period. The indices of renal function (BUN, Cr, CCr) showed no significant change before, during and after the treatment with the ACE-I.In this study, the animal models of chronic renal failure demonstrated renal hypertension, which was obviously reversed by the ACE-I without advancing the renal disorder. It has been therefore suggested that the management of high blood pressure, which is one of the factors aggravating the condition of chronic renal failure, could stop the progression of chronic renal failure and ACE-I's are of great benefit to small animal patients with hypertension in future. Less

最近，像人类患者一样，小型动物诊所中慢性肾衰竭的病例有所增加。已经进行了诊断和治疗的方法学研究，但尚未提出肾性高血压的详细描述。因此，我们在此报告了肾脏疾病对慢性肾衰竭猫模型中肾性高血压发病机制的可能贡献，使用遥测系统可以连续24小时监测清醒、不受约束的动物的血压，重点关注血压和肾素-血管紧张素-也甾酮系统中的某些参数。此外，我们将描述血管紧张素转换酶抑制剂对目前慢性肾衰竭动物模型中肾性高血压的作用。 [结果] 对 5 只猫的肾功能评估显示，与术前相比，慢性肾衰竭手术后 BUN 和血清 Cr 水平显着升高 (p<0.05)，CCr 显着降低 (p<0.05)。此外，术后收缩压、平均压和舒张压均显着高于对照值（p<0.05）。术后血浆肾素活性、血管紧张素I（ANG-I）、血管紧张素II（ANG-II）和ALD均较术前显着升高（p<0.05）。在慢性肾功能衰竭的动物模型中，与治疗前水平相比，盐酸苯那普利在治疗期间使收缩压、平均压和舒张压显着下降（p<0.05）。停药后压力恢复到与治疗前几乎相同的水平。同时，ACE-I导致治疗期间血浆血管紧张素II和ALD显着降低（p<0.05），停药后持续低水平。另一方面，在观察期间，ACE-I 没有改变血浆肾素活性或血管紧张素 I (ANG-I) 水平。肾功能指标（BUN、Cr、CCr）在ACE-I治疗前、治疗期间和治疗后均无明显变化。在本研究中，慢性肾衰竭动物模型表现出肾性高血压，ACE-I可明显逆转这种情况，且不会加重肾脏疾病。因此，有人建议，高血压是慢性肾功能衰竭病情加重的因素之一，高血压的治疗可以阻止慢性肾功能衰竭的进展，而ACE-I对未来患有高血压的小动物患者大有裨益。较少的

项目成果

Mika Mishina,Toshifumi Watanabe, et al.: "A Clinical Evaluation of Blood Pressure through Non-Invasive Measurement Using the Oscillometric Procedure in Conscious Dogs"J.Vet.Med.Sci.. 59(11). 989-993 (1997)

Mika Mishina、Toshifumi Watanabe 等人：“使用示波法对有意识的狗进行无创测量血压的临床评估”J.Vet.Med.Sci. 59(11)。

Mika Mishina, et al: "Diural Variation of Blood Pressure in Dogs"J.Vet.Med.Sci. 61(6). 643-647 (1999)

Mika Mishina 等人：“狗血压的昼夜变化”J.Vet.Med.Sci。

Mika Mishina,Toshifumi Watanabe, et al.: "Non-invasive Blood Pressure Measurements in cats: Clonical Significance of Hypertension Associated with Chronic Renal Failure"J.Vet.Med.Sci.. 60(7). 805-808 (1998)

Mika Mishina、Toshifumi Watanabe 等人：“猫的无创血压测量：与慢性肾功能衰竭相关的高血压的克隆意义”J.Vet.Med.Sci. 60(7)。

Mika Mishina, et al.: "Diurnal Variations of Blood Pressure in Dogs"J.Vet.Med.Sci.. 61(6). 643-647 (1999)

Mika Mishina 等人：“狗血压的昼夜变化”J.Vet.Med.Sci. 61(6)。

Mika Mishina, et al: "Non-invasive Blood Pressure Measurement in Cats: Clinical Significance of Hypertension Associated with CRF"J.Vet.Med.Sci. 60(7). 805-808 (1998)

Mika Mishina 等人：“猫的无创血压测量：与 CRF 相关的高血压的临床意义”J.Vet.Med.Sci。