MR顕微鏡を用いた肺の病理のMR診断に関する基礎的研究

MR显微镜MR诊断肺部病理的基础研究

• 批准号: 10877136
• 负责人: 吉川 宏起
• 金额: $ 1.22万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Exploratory Research
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10877136/
• 关键词: MR顕微鏡; 肺ファントム; 肺病理

1)高分解能MR顕微鏡を設計し作成。最大磁場勾配23mT/m下におけるMR顕微鏡用のコイルを作成し、マトリックス256×256で20mm×20mmから10mm×10mmのピクセルサイズの画像を得ることができた。装置は医科学研究所附属病院放射線科が現有する米国GE社製Signa Horizon5.6version(1.5T)であった。2)肺ファントムを作成。高分解能MR顕微鏡の空間分解能を求めるために、肺のファントムを作成した。水と数種の濃度のアルブミン溶液(5,10,20,30g/dl)はヒトの肺の密度に近い0.3g/mlとなるよう海綿に吸収させた。3次元グラディエントエコー法を用いたMR画像上では、アルブミン水溶液に浸したファントム(海綿)ではアルブミン濃度が低いとき(5g/dl,10g/dl)には水との違いを分別することは困難であった。しかし、20、30g/dlのときには水との信号強度に差がみとめられ、ファントムとして用いることができた。3)ラットに生理食塩水と、オレイン酸を注入し、肺浮腫を生じさせた。4)種々の条件下で肺ファントムを用いてMR顕微鏡での最適な撮像方法及びパルスシークエンスを求めた。5)上記最適条件下におけるラットの実験肺浮腫モデル及び実際の剖検肺を用いて撮像を行った。正常肺と線維化、肺浮腫、出血、腫瘍等の病変のある剖検肺にHeizman固定を行い、病変部を撮像し、光学顕微鏡下の所見と比較が行えた。今後はホルマリン固定を行った場合と行わない場合のMR所見の相違の検討及びMR所見と組織肺の水分量との相関関係を検討していく予定である。

The main results are as follows: 1) High decomposition can be made by MR micrometer design. The maximum magnetic field is matched to the 23mT/m. The MR microphone is made with the microphone, and the portrait is made of the image that is made of 256x256x256x256x256xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx In the Department of Radiology, affiliated Hospital of the Institute of Medical Sciences, the Department of Radiology is equipped with the American GE Society Signa Horizon5.6version (1.5T). 2) the lungs and lungs were made. High decomposition energy MR micro-space decomposition can be used to calculate the temperature of the lung and the lung. The lung density was measured by using several different concentrations of water (5, 10, 20, 30, dl). The density of the lungs was measured, and the density of the lungs was measured. The density of the lungs was close to that of 0.3g/ml, and the sea water was very sensitive. The three-dimensional method was used to measure the size of the MR portrait, the water solution, the temperature, the The strength of the signal is different from that of the 30g/dl signal. 3) normal diet, acid injection and lung floatation. 4) under different conditions, we use the most accurate image preparation method of MR micrograph and the most accurate image processing method for lung cancer. 5) under the most suitable conditions, the lungs were removed from the lungs and the lungs were dissected under the best conditions. Normal lung maintenance, lung floatation, hemorrhage, and other diseases were performed. The lung was fixed by Heizman, the pathological part was photographed, and the results were compared under the optical micrograph. In the future, the lung water content of the tissue seen by MR and MR will be determined by the determination of lung water content.

项目成果

Yusuke Inoue: "Evaluation of flow characteristics of soft-tissue vascular malformations using technetium-99m red blood cells"Eur. J. Nucl. Med.. 26・4. 367-372 (1999)

Yusuke Inoue：“使用锝-99m红细胞评估软组织血管畸形”Eur. J. Nucl. 367-372 (1999)

Kokki Yoshikawa: "Safety of Proteance in special PoPulations" European Radiology. 7. 246-250 (1997)

Kokki Yoshikawa：“特殊人群中保护的安全性”欧洲放射学。