MEASUREMENT OF OPTICAL ROTATORY POWER OF CRYSTALS

在溶液相中测定了许多手性化合物的旋光性。相比之下，晶体状态下的旋光数据一直很稀少，因为由于晶体的双折射率比旋光功率大10^3倍，测量非常困难。在我们的研究中，我们希望从不同的非手性分子制备手性共晶和通过固相反应的共晶的绝对不对称合成，手性晶体的光学活性的测量。本文介绍了一种晶体专用旋光仪HAUP（High Accuracy Universal Polarimeter），这是第一台商品化的仪器。我们成功地测定了由色胺和对氯苯甲酸合成的手性共晶体的旋光强度。因为有机晶体是软的，所以通过抛光来制备样品并不容易。为了进一步发展固态手性化学，我们正在继续进行进一步的研究，如2002 - 2003年科学研究资助项目（B）（2）"手性晶体的圆二色性"。

Optical activity properties of numbers of chiral compounds have been measured in solution phase. In contrast, optical activity data in crystalline state have been scarce, because the measurement is very difficult due to the larger birefringence of crystal by 10^3 fold than optical rotatory power. In our study of preparation of chiral cocrystals from different achiral molecules and absolute asymmetric synthesis by solid state reaction of the cocrystals, we would like to measure optical activity properties of chiral crystals. Herein we introduced a special polarimeter for crystals HAUP (High Accuracy Universal Polarimeter), which is the first commercially available apparatus. We successfully measured the optical rotatory power of chiral cocrystal from tryptamine and 4-chlorobenzoic acid which we prepared. Because organic crystals are soft, sample preparation by polish is not easy. The problem for the sample processing should be resolved in future.Further research is now continued in order to develop solid state chiral chemistry, as Grant-in-aid for Scientific Research (B)(2), "Circular Dichroims of Chiral Crystals" in 2002-2003.