MEASUREMENT OF OPTICAL ROTATORY POWER OF CRYSTALS

测定了一些手性化合物在溶液相中的旋光性质。相反，由于晶体的双折射比旋光率大10^3倍，因此晶体在晶态下的光学活性数据一直很少，测量非常困难。在由不同的非手性分子制备手性共晶体以及利用这些共晶的固相反应进行绝对不对称合成的研究中，我们想要测量手性晶体的光学活性。在此，我们介绍了一种用于晶体的专用旋光仪HAUP(高精度通用偏振仪)，这是第一个商业化的仪器。我们成功地测量了我们制备的色胺和对氯苯甲酸的手性共晶体的旋光率。由于有机晶体很软，通过抛光来制备样品并不容易。为了发展固态手性化学，目前还在继续进行进一步的研究，如2002-2003年的科学研究助学金(B)(2)《手性晶体的圆二色谱》。

Optical activity properties of numbers of chiral compounds have been measured in solution phase. In contrast, optical activity data in crystalline state have been scarce, because the measurement is very difficult due to the larger birefringence of crystal by 10^3 fold than optical rotatory power. In our study of preparation of chiral cocrystals from different achiral molecules and absolute asymmetric synthesis by solid state reaction of the cocrystals, we would like to measure optical activity properties of chiral crystals. Herein we introduced a special polarimeter for crystals HAUP (High Accuracy Universal Polarimeter), which is the first commercially available apparatus. We successfully measured the optical rotatory power of chiral cocrystal from tryptamine and 4-chlorobenzoic acid which we prepared. Because organic crystals are soft, sample preparation by polish is not easy. The problem for the sample processing should be resolved in future.Further research is now continued in order to develop solid state chiral chemistry, as Grant-in-aid for Scientific Research (B)(2), "Circular Dichroims of Chiral Crystals" in 2002-2003.