MEASUREMENT OF OPTICAL ROTATORY POWER OF CRYSTALS

晶体旋光度的测量

• 批准号: 11304051
• 负责人: KOSHIMA Hideko
• 金额: $ 22.21万
• 依托单位: EHIME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11304051/
• 关键词: OPTICAL ACTIVITY; OPTICAL ROTATORY POWER; CHIRAL CRYSTALS; CHIRAL COCRYSTALS; ACHIRAL MOLECULES; CHlRAL CRYSTALLIZATION; HELIX; ENAMIOCONTROL; キラリティー; エナンチオマー; 結晶施光能

Optical activity properties of numbers of chiral compounds have been measured in solution phase. In contrast, optical activity data in crystalline state have been scarce, because the measurement is very difficult due to the larger birefringence of crystal by 10^3 fold than optical rotatory power. In our study of preparation of chiral cocrystals from different achiral molecules and absolute asymmetric synthesis by solid state reaction of the cocrystals, we would like to measure optical activity properties of chiral crystals. Herein we introduced a special polarimeter for crystals HAUP (High Accuracy Universal Polarimeter), which is the first commercially available apparatus. We successfully measured the optical rotatory power of chiral cocrystal from tryptamine and 4-chlorobenzoic acid which we prepared. Because organic crystals are soft, sample preparation by polish is not easy. The problem for the sample processing should be resolved in future.Further research is now continued in order to develop solid state chiral chemistry, as Grant-in-aid for Scientific Research (B)(2), "Circular Dichroims of Chiral Crystals" in 2002-2003.

在溶液相中测定了许多手性化合物的旋光性。相比之下，晶体状态下的旋光数据一直很稀少，因为由于晶体的双折射率比旋光功率大10^3倍，测量非常困难。在我们的研究中，我们希望从不同的非手性分子制备手性共晶和通过固相反应的共晶的绝对不对称合成，手性晶体的光学活性的测量。本文介绍了一种晶体专用旋光仪HAUP（High Accuracy Universal Polarimeter），这是第一台商品化的仪器。我们成功地测定了由色胺和对氯苯甲酸合成的手性共晶体的旋光强度。因为有机晶体是软的，所以通过抛光来制备样品并不容易。为了进一步发展固态手性化学，我们正在继续进行进一步的研究，如2002-2003年科学研究资助项目（B）（2）“手性晶体的圆二色性”。

项目成果

H.Koshima,D.Matsushige,M.Miyauchi,and J.Fujita: "Solid State Photoreaction in Two-Component Molecular Crystals of Thienylacetic Acids and Aza Aromatic Compounds"Tetrahedron. 56. 6845-6852 (2000)

H.Koshima、D.Matsushige、M.Miyauchi 和 J.Fujita：“噻吩基乙酸和氮杂芳香族化合物的双组分分子晶体中的固态光反应”四面体。

H.Koshima and S.Honke: "Chiral Bimolecular Crystallization of Tryptamine and Achiral Carboxylic Acids"Journal of Organic Chemistry. 64. 790-793 (1999)

H.Koshima 和 S.Honke：“色胺和非手性羧酸的手性双分子结晶”有机化学杂志。

H.Koshima,S.Honke and M.Miyauchi: "Preparation of Helical-type Crystals from Tryptamine and Achiral Carboxylic Acids and Their Enantiomorphous Control by Pseudo-s"Molecular Crystals and Liquid Crystals. (in press).

H.Koshima，S.Honke 和 M.Miyauchi：“从色胺和非手性羧酸制备螺旋型晶体及其通过伪-s”分子晶体和液晶的对映体控制。

H.Koshima, S.Honke, M.Miyauchi: "Enantiomorphous Control in Chiral Crystallization of Achiral Molecules by Pseudo-Seeding"Enantiomer. 5. 125-128 (2000)

H.Koshima、S.Honke、M.Miyauchi：“通过伪晶种对非手性分子的手性结晶进行对映体控制”对映体。

H.Koshima, M.Miyauchi: "Polymorphs of a Co-crystal with Achiral and Chiral Structures Prepared by Pseudo-seeding: Tryptamine/Hydrocinnamic Acid"Cryst. Growth Des.. 1. 355-357 (2001)

H.Koshima，M.Miyauchi：“通过伪晶种制备的具有非手性和手性结构的共晶的多晶型物：色胺/氢化肉桂酸”晶体。