Xenogeneic per fusion experiment and treatment for patients with liver failure using a non woven fabric bioreactor.

点击翻译按钮获取中文摘要

We developed a new system of xenogeneic direct hemoperfusion of bioartificial liver support consisting of a leukocyte adsorbent, an immunoglobulin adsorbent, and a substitute unit for hepatic function, that is, whole liver or bioreactor. A further improvement of our system by incorporating a leukocytapheresis (LCAP) device to return the leukocyte-rich portion of the per fused blood back to the patient's body directly was undergone. Influx of porcine endogenous retrovirus (PERV) into the human body has been a controvertial subject. We developed resusciteting separated plasma per fusion method, which are promising in that the patient's circuit and the bioartificial liver circuit are separated by a semipermiable membrane, which can prevent any kind of virus from flowing into the patient's circuit.