Unravelling the mechanisms of sodium-selectivity in biological ion channels

揭示生物离子通道中钠选择性的机制

• 批准号: DP220103550
• 负责人: Prof Toby Allen
• 金额: $ 26.28万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-08-22 至 2025-08-21
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220103550
• 关键词: Unravelling; mechanisms; sodium; selectivity; biological

The aim of this project is to determine the origins of protein-mediated sodium ion transport across cell membranes. The project expects to reveal the mechanisms of selective ion conduction in different sodium-selective ion channels using advanced computer simulations, in concert with non-canonical mutation experiments that target the roles of protein chemistry. The expected outcome is improved understanding of how proteins discriminate between ion species, challenging theories that have stood for decades. The results should provide benefits in the form of basic understanding relevant to ion transport phenomena in biology and novel materials, with atomic-level views of nervous system function to guide future directions in drug development.

这个项目的目的是确定蛋白质介导的钠离子跨细胞膜运输的起源。该项目希望利用先进的计算机模拟，结合针对蛋白质化学作用的非规范突变实验，揭示不同钠选择性离子通道中选择性离子传导的机制。预期的结果是提高对蛋白质如何区分离子种类的理解，挑战几十年来的理论。这些结果将有助于对生物学和新材料中的离子传输现象进行基本理解，并从原子水平上观察神经系统功能，以指导未来药物开发的方向。