Uncovering the molecular mechanisms of potassium channel activity.

揭示钾通道活性的分子机制。

• 批准号: DP210102405
• 负责人: Prof Toby Allen
• 金额: $ 30.86万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-05-14 至 2024-05-13
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210102405
• 关键词: Uncovering; molecular; mechanisms; potassium; channel

The aim of this project is to determine the mechanisms of protein-mediated potassium ion transport across cell membranes. It will combine advanced simulations, structural biology and electrophysiology to describe the detailed molecular processes underscoring calcium-activated potassium channel conduction, gating and inactivation. The expected outcome is an improved description of how ion channels recognise and respond to physiological stimuli to control electrical signalling the body. Our results will provide benefits in the form of basic understanding relevant to ion transport phenomena in biological systems, and atomic-level views of nervous system function to guide future directions in pharmacology.

这个项目的目的是确定蛋白质介导的钾离子跨细胞膜运输的机制。它将结合先进的模拟、结构生物学和电生理学来描述钙活化钾通道传导、门控和失活的详细分子过程。预期的结果是对离子通道如何识别和响应生理刺激以控制身体电信号的改进描述。我们的研究结果将有助于对生物系统中离子传输现象的基本理解，以及神经系统功能的原子水平观点，以指导未来药理学的发展方向。