In depth investigation of the molecular signaling mechanisms and cellular function of midkine, neuropilin-2 and sFLT1 in conjunctival and uveal melanoma (C03)

深入研究中期因子、神经毡蛋白-2和sFLT1在结膜和葡萄膜黑色素瘤中的分子信号机制和细胞功能（C03）

• 批准号: 529571611
• 金额: --
• 依托单位: Zentrum für Augenheilkunde
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/529571611?language=en
• 关键词: depth; investigation; molecular; signaling; mechanisms

To develop effective therapies for metastatic ocular melanoma, it is of utmost importance to understand the underlying cellular and molecular mechanisms behind metastasis in ocular melanoma. In our previous studies, we were able to identify that lymphangiogenesis is a decisive risk factor for metastatic spread in ocular melanoma. In the present project, the characterization of cellular functions and molecular signaling pathways involving the key drivers of ocular tumor metastasis, Midkine, NRP2 and sFLT1, are studied with the long-term goal to translate our findings into clinically used (neo)adjuvant, antilymphatic therapeutic strategies for ocular melanoma patients.

为了开发有效的眼部转移性黑色素瘤的治疗方法，了解眼部黑色素瘤转移背后的潜在细胞和分子机制是至关重要的。在我们之前的研究中，我们能够确定淋巴管生成是眼部黑色素瘤转移扩散的决定性危险因素。在本项目中，对涉及眼肿瘤转移的关键驱动因素Midkine、NRP2和sFlt1的细胞功能和分子信号通路的特征进行了研究，以期将我们的发现转化为临床使用的(NEO)辅助和抗淋巴管治疗策略，用于眼部黑色素瘤患者。