Optical Resolution Membrane from Main-chin Chiral Polymer

1.主链型手性聚合物的合成我们发现当各种乙炔中含有大体积的手性取代基时，主链型手性聚合物都被诱导出来。当取代基靠近主链时，不对称诱导是有效的。仅在主链上具有手性的手性聚合物的合成为了阐明对映选择性渗透的影响，我们研究了仅在主链上具有手性的手性聚合物的合成方法。我们能够通过羟基苯乙炔与铑-手性胺催化体系的聚合来合成这样的聚合物。所得聚合物具有成膜能力.主链型手性聚合物膜的光学拆分由1中得到的聚合物膜显示出高的对映选择性渗透。手性取代基的含量也很重要.通过仅在主链中具有手性的手性聚合物的膜的光学拆分由于来自在2中获得的聚合物的膜在渗透中显示出对映选择性，因此证实了时间主链手性对于分离是有效的。我们研究了CD信号强度与选择性之间的关系.主链手性对手性渗透的影响从3和4的结果来看，主链手性对手性渗透非常有效。

1. Synthesis of Main-chain Chiral PolymersWe found main-chain chirality was induced when various kind of acetylene having a bulky chiral substituent. The asymmetric induction was effective when the bulky substituent is close to the main-chain.2. Syntheses of Chiral Polymers that have the chirality only in the main-chainTo clarify the effect on the enantioselective permeation, we examined synthetic methods of chiral polymers having the chirality only in the main-chain. We were able to synthesize such polymers by polymerization of a hydroxyphenylacetylene with rhodium-chiral amine catalytic system. The resulting polymers had a membrane-forming ability.3. Optical Resolution by Membranes of Main-chain Chiral PolymersMembranes from the polymers obtained in 1 showed high enantioselectivity in permeation. The content of the chiral substituent was also found to be important.4. Optical Resolution by Membranes of Chiral Polymers that have the chirality only in the main-chainSince membranes from the polymers obtained in 2 showed enantioselectivity in permeation, it was confirmed that time main-chain chirality was effective for the separation. We examined the relationship between the strength of CD signal and the selectivity.5. Effect of the main-chain chirality on enantioselective permeationFrom the results of 3 and 4, The main-chain chiralities were very effective for enantioselective permeation.