Optical Resolution Membrane from Main-chin Chiral Polymer

点击翻译按钮获取中文摘要

1. Synthesis of Main-chain Chiral PolymersWe found main-chain chirality was induced when various kind of acetylene having a bulky chiral substituent. The asymmetric induction was effective when the bulky substituent is close to the main-chain.2. Syntheses of Chiral Polymers that have the chirality only in the main-chainTo clarify the effect on the enantioselective permeation, we examined synthetic methods of chiral polymers having the chirality only in the main-chain. We were able to synthesize such polymers by polymerization of a hydroxyphenylacetylene with rhodium-chiral amine catalytic system. The resulting polymers had a membrane-forming ability.3. Optical Resolution by Membranes of Main-chain Chiral PolymersMembranes from the polymers obtained in 1 showed high enantioselectivity in permeation. The content of the chiral substituent was also found to be important.4. Optical Resolution by Membranes of Chiral Polymers that have the chirality only in the main-chainSince membranes from the polymers obtained in 2 showed enantioselectivity in permeation, it was confirmed that time main-chain chirality was effective for the separation. We examined the relationship between the strength of CD signal and the selectivity.5. Effect of the main-chain chirality on enantioselective permeationFrom the results of 3 and 4, The main-chain chiralities were very effective for enantioselective permeation.