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Optical Resolution Membrane from Main-chin Chiral Polymer

主钦手性聚合物光学分离膜

基本信息

批准号：
11650906
负责人：
AOKI Toshiki
金额：
$ 2.24万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650906/
关键词：
Main-chain Chirality Asymmmetric Polymerization Separation Membrane Optical Resolution Phenylacetylene

项目摘要

1. Synthesis of Main-chain Chiral PolymersWe found main-chain chirality was induced when various kind of acetylene having a bulky chiral substituent. The asymmetric induction was effective when the bulky substituent is close to the main-chain.2. Syntheses of Chiral Polymers that have the chirality only in the main-chainTo clarify the effect on the enantioselective permeation, we examined synthetic methods of chiral polymers having the chirality only in the main-chain. We were able to synthesize such polymers by polymerization of a hydroxyphenylacetylene with rhodium-chiral amine catalytic system. The resulting polymers had a membrane-forming ability.3. Optical Resolution by Membranes of Main-chain Chiral PolymersMembranes from the polymers obtained in 1 showed high enantioselectivity in permeation. The content of the chiral substituent was also found to be important.4. Optical Resolution by Membranes of Chiral Polymers that have the chirality only in the main-chainSince membranes from the polymers obtained in 2 showed enantioselectivity in permeation, it was confirmed that time main-chain chirality was effective for the separation. We examined the relationship between the strength of CD signal and the selectivity.5. Effect of the main-chain chirality on enantioselective permeationFrom the results of 3 and 4, The main-chain chiralities were very effective for enantioselective permeation.

1. 主链手性聚合物的合成我们发现，当各种乙炔具有大量的手性取代基时，主链手性被诱导。当体积较大的取代基靠近主链时，不对称诱导是有效的。为了阐明手性对对映选择性渗透的影响，我们研究了只具有主链手性的手性聚合物的合成方法。我们可以用一种羟基苯乙炔与铑-手性胺催化体系聚合合成这种聚合物。所得聚合物具有成膜能力。主链手性聚合物膜的光学分辨1中获得的聚合物膜在渗透方面表现出很高的对映选择性。手性取代基的含量也很重要。仅在主链上具有手性的手性聚合物膜的光学分离由于2中获得的聚合物膜在渗透中表现出对映选择性，因此证实了时间主链手性对分离是有效的。我们研究了CD信号强度与选择性之间的关系。主链手性对对映选择性渗透的影响从3和4的结果可以看出，主链手性对对映选择性渗透是非常有效的。