Mechanism and Optimization of Diffusion controlled enantioselective permeable membrane

扩散控制对映选择性渗透膜的机理及优化

• 批准号: 13555213
• 负责人: AOKI Toshiki
• 金额: $ 4.61万
• 依托单位: NIIGATA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13555213/
• 关键词: Optical resolution membrane; Permeation condition; Pervaporation; Depinnaylsilation; 2-butanol; Chiral helical polymer; 製膜条件; ピナニルシリル基

We have synthesized new well-defined polymers and developed optical resolution membranes which have high enantioselevtivity from these polymers. We proposed the separations occurred in diffusion process. However, the reason and detail were not clear and their permeation rates were low. In this study, several optimizations were carried out in these membrane process. For example, molecular structures, conditions in membrane preparation and permeation were examined.First, several new optically active polymers were synthesized. Especially, we have discovered new polymerization method to obtain chiral helical polymers. In addition, new chiral helical polymers were prepared by condensation polymerization.Secondly, we confirmed the separation of these membrane process occurred in diffusion process. In addition, chiral helicity was found to be effective for enantioselective permeation. In particular, we found that polymeric membranes whose chiral groups had been removed by reaction in membrane state showed enantioselective permeability.Lastly, thin membranes such as composite membranes and asymmetric membranes were prepared. High permeation was realized by using these thin membranes. Pervaporation was also tried to make the rate higher.In conclusion, we attained higher permeability and obtained many findings for practical use.

我们合成了新的定义良好的聚合物，并用这些聚合物开发了具有高对映选择性的光学拆分膜。提出了扩散过程中发生的分离现象。然而，其原因和细节尚不清楚，渗透率较低。在本研究中，对这些膜过程进行了几项优化。首先，合成了几种新型的光学活性聚合物。特别是，我们发现了获得手性螺旋聚合物的新的聚合方法。此外，通过缩聚反应合成了新型手性螺旋聚合物。其次，我们证实了这些膜过程在扩散过程中发生了分离。此外，手性螺旋度对手性选择性渗透也有一定的影响。特别是，我们发现在膜状态下通过反应去除了手性基团的聚合物膜具有对映体选择性透过性。最后，制备了复合膜和不对称膜等薄膜。利用这些薄膜实现了高渗透。此外，我们还尝试了渗透汽化的方法来提高渗透率。总之，我们获得了更高的渗透率，并得到了许多具有实际应用价值的研究结果。

项目成果

Toshiki Aoki: "Optical Resolution Membranes"Chemical Industry. 52(9). 683-691 (2001)

青木敏树：“光学分辨率膜”化学工业。

Toshiki Aoki: "Helix-Sense-Selective Polymerization of Achiral Phenylacetylene Having Two Hydroxy Groups Using a Chiral Catalytic System"J.Am.Chem.Soc.. 125(21). 6346-6347 (2003)

Toshiki Aoki：“使用手性催化系统对具有两个羟基的非手性苯乙炔进行螺旋正义选择性聚合”J.Am.Chem.Soc.. 125(21)。

Masahiro Teraguchi: "Enantioselective Permeation through Membranes of Chiral Helical Polymers Prepared by Depinanylsilylation of Poly(dphenylacetylene) with High Content of Pinanylsilyl Group"Macromolecules. 36(26). 9694-9697 (2003)

Masahiro Teraguchi：“通过对高含量蒎烯基甲硅烷基的聚（二苯基乙炔）进行脱蒎酰甲硅烷基化制备的手性螺旋聚合物膜的对映选择性渗透”大分子。

Ken-ichi Shinohara: "Helical chirality π-conjugated main-chain induced by polymerization of phenylacetylene with chiral bulky pinanyl groups"J.Polym.Sci., PartA : Polym.Chem.. 40. 1689-1697 (2002)

Ken-ichi Shinohara：“由苯乙炔与手性大蒎基聚合诱导的螺旋手性 π 共轭主链”J.Polym.Sci.，PartA：Polym.Chem.. 40. 1689-1697 (2002)

Masahiro Teraguchi: "Enantioselective Permeation through Membranes of Chiral Helical Polymers Prepared by Depinanylsilylation of Poly(dphenylacetylene) with High Content of Pinanylsilyl Group"Macromolecules. 36. 9694-9697 (2003)

Masahiro Teraguchi：“通过对高含量蒎烯基甲硅烷基的聚（二苯基乙炔）进行脱蒎酰甲硅烷基化制备的手性螺旋聚合物膜的对映选择性渗透”大分子。