Preventive effect of seaweed on the disorder of blood circulation and its application to food

海藻对血液循环障碍的预防作用及其在食品中的应用

• 批准号: 11660202
• 负责人: AMANO Hideomi
• 金额: $ 2.3万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11660202/
• 关键词: Seaweed; Monostroma nitidum; Undaria pinnatifida; Hijikia fusiformis; Laminalia japonica; Platelets anti-aggregation; Erythrocyte deformability; Blood fluidity; 海苔; 血液循環障害防止; ミネラル; アミノ酸; D-システノール酸; 海藻食品; カラゲナン; ポルフィラン; リン脂質

To study preventive effect of seaweed on the disorder of blood circulation and its application to food, several edible seaweed were examined on blood anti-coagulation erythrocyte deformabilrty, and platelets anti-aggregation by in vitro and in vivo experiments.By in vitro experiment, among several edible algae, Hijikia fusiformis (Hijiki), Undaria pinnatifida (Wakame), Monostroma nitidium (Hitoegusa) and Laminaria japonica (Makombu) lowered the blood coagulation time to 93 %, 95 %, 97 % and 98 %, respectively. Among seaweed components, minerals of H. fusiformis, U. pinnatifida, M nitidum, L. japonica increased the erythrocyte deformability 18 %, 14 %, 14 %, 11 %, respectively. These effects were caused mainly by the Ca/Mg ratio. Phospholipid, κ-carrageenan, porphyran, and D-cysteinolic acid of M. nitidum also increased the erythrocytes deformability. Monostraoma minerals were useful not only increase the erythrocytes deformability but also inhibit the decrease of its deformability. When tested by animal experiments. Monostrom minerals inhibited the decrease of erythrocyte deformability, shortened APTT and inhibited the platelets aggregation activity. Cr, Se and Mg in the minerals were assumed to be effective factor. Using M. nitidum, new food "Nori tukudani " having the effects of minerals and D-cysteinolic acid that have platelets anti-aggregating effects were developed. Therefore, usage of M. nitidum in daily eating habits improves health from the view point of blood fluidity.

为研究海藻对血液循环障碍的预防作用及其在食品中的应用，通过体外实验和体内实验，对几种食用海藻的抗凝血、红细胞变形性和抗血小板聚集作用进行了研究，结果表明：在体外实验中，羊栖菜、裙带菜、光膜和海带分别使凝血时间降低93%、95%、97%和98%。在海藻成分中，H. fusiformis、梭形U. pinnatifida、M nitidum、L.使红细胞变形能力分别提高18%、14%、14%、11%。这些影响主要是由Ca/Mg比引起的。M.的磷脂、κ-卡拉胶、卟啉和D-半胱氨酸。还可增加红细胞变形性。海藻矿物质不仅能提高红细胞变形能力，而且能抑制红细胞变形能力的下降。当通过动物实验测试时。Monostrom矿物质可抑制红细胞变形能力的下降，缩短APTT，抑制血小板聚集活性。矿物中的Cr、Se、Mg可能是其影响因素。利用M.开发了具有抗血小板聚集作用的矿物质和D-半胱氨酸作用的新食品“紫菜“。因此，使用M。从血液流动性的角度来看，日常饮食习惯中的两面针可以改善健康。